Stevens J C, Farlow M R, Edwards M K, Yu P L
Arch Neurol. 1986 Nov;43(11):1145-8. doi: 10.1001/archneur.1986.00520110039011.
Sixty-four patients with possible, probable, or definite multiple sclerosis (McAlpine criteria) were clinically evaluated using the expanded disability status scale (EDSS) and Scripps neurologic rating scale (NRS). All were examined with a 0.15T magnetic resonance scanner using T2- and T1-weighted images. Correlations between EDSS and NRS scores and severity of disease detected on magnetic resonance imaging were determined. Significant correlations existed between EDSS and NRS with magnetic resonance ratings. Moderate correlations were observed in the motor, cerebellar, and brainstem subgroups of the clinical scales. Significant low correlations existed in the mood/mentation, vision (optic nerves), and bowel/bladder subgroups. Clinical and neuroimaging limitations may account for the lack of higher correlations. Significant correlations suggest the utility of magnetic resonance imaging in monitoring disease progression, and it may prove to be the technique of choice in following up patients with multiple sclerosis.
根据麦克阿尔平标准，对64例可能、很可能或确诊的多发性硬化症患者，使用扩展残疾状态量表（EDSS）和斯克里普斯神经学评定量表（NRS）进行临床评估。所有患者均使用0.15T磁共振扫描仪，采用T2加权和T1加权图像进行检查。确定了EDSS和NRS评分与磁共振成像检测到的疾病严重程度之间的相关性。EDSS和NRS与磁共振评分之间存在显著相关性。在临床量表的运动、小脑和脑干亚组中观察到中度相关性。在情绪/精神状态、视觉（视神经）和肠道/膀胱亚组中存在显著低相关性。临床和神经影像学的局限性可能是缺乏更高相关性的原因。显著相关性表明磁共振成像在监测疾病进展方面的实用性，并且它可能被证明是对多发性硬化症患者进行随访的首选技术。
