Ashtari Fereshteh, Emami Parisa, Akbari Mojtaba
Isfahan Neurosciences Research Center, Alzahra Hospital, Isfahan, Iran ; Department of Neurology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Epidemiology, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran.
Adv Biomed Res. 2015 Oct 7;4:223. doi: 10.4103/2277-9175.166646. eCollection 2015.
Multiple Sclerosis (MS) is a neurological disease in which demyelination and axonal loss leads to progressive disability. Cognition impairment is among the most common complication. Studying axonal loss in the retina is a new marker for MS. The main goal of our study is to search for correlations between magnetic resonance imaging (MRI) findings and the retinal nerve fiber layer (RNFL) thickness at the macula and head of the optic nerve and Wechsler Adult Intelligence Scale-Revised (WAIS-R) Scores that assess multiple domains of intelligence, and to explore the relationship between changes in the RNFL thickness with intellectual and cognitive dysfunction.
A prospective cross-sectional study was conducted at the University Hospital of Kashani, Isfahan, Iran, from September to December 2013. All patients were assessed with a full-scale intelligence quotient (IQ) on the WAIS-R. An optical coherence tomography study and brain MRI were performed in the same week for all the patients. Statistical analysis was conducted by using a bivariate correlation, by utilizing SPSS 20.0. A P value ≤ 0.05 was the threshold of statistical significance.
Examination of a 100 patients showed a significant correlation between the average RNFL thickness of the macula and the verbal IQ (P value = 0.01) and full IQ (P value = 0.01). There was a significant correlation between brain atrophy and verbal IQ.
The RNFL loss was correlated with verbal IQ and full IQ.
多发性硬化症（MS）是一种神经疾病，其中脱髓鞘和轴突损失会导致进行性残疾。认知障碍是最常见的并发症之一。研究视网膜中的轴突损失是MS的一种新标志物。我们研究的主要目标是寻找磁共振成像（MRI）结果与黄斑和视神经头部的视网膜神经纤维层（RNFL）厚度以及评估多个智力领域的韦氏成人智力量表修订版（WAIS-R）分数之间的相关性，并探讨RNFL厚度变化与智力和认知功能障碍之间的关系。
2013年9月至12月在伊朗伊斯法罕卡尚大学医院进行了一项前瞻性横断面研究。所有患者均接受了WAIS-R的全量表智商（IQ）评估。所有患者在同一周内进行了光学相干断层扫描研究和脑部MRI检查。使用SPSS 20.0进行双变量相关性统计分析。P值≤0.05为统计学显著性阈值。
对100名患者的检查显示，黄斑平均RNFL厚度与言语智商（P值 = 0.01）和全量表智商（P值 = 0.01）之间存在显著相关性。脑萎缩与言语智商之间存在显著相关性。
RNFL损失与言语智商和全量表智商相关。
