Department of Internal Medicine, AMC, University of Amsterdam, The Netherlands.
Best Pract Res Clin Gastroenterol. 2013 Feb;27(1):127-37. doi: 10.1016/j.bpg.2013.03.003.
Recent studies have suggested an association between intestinal microbiota composition and human disease, however causality remains to be proven. With hindsight, the application of fecal transplantation (FMT) does indeed suggest a causal relation between interfering with gut microbiota composition and a resultant cure of several disease states. In this review, we aim to show the available evidence regarding the involvement of intestinal microbiota and human (autoimmune) disease. Moreover, we refer to (mostly case report) studies showing beneficial or adverse effects of fecal transplantation on clinical outcomes in some of these disease states. If these findings can be substantiated in larger randomized controlled double blind trials also implementing gut microbiota composition before and after intervention, fecal transplantation might provide us with novel insights into causally related intestinal microbiota, that might be serve as future diagnostic and treatment targets in human disease.
最近的研究表明肠道微生物组成与人类疾病之间存在关联，但因果关系仍有待证明。事后看来，粪便移植（FMT）的应用确实表明，干扰肠道微生物组成与某些疾病状态的治愈之间存在因果关系。在这篇综述中，我们旨在展示关于肠道微生物与人类（自身免疫）疾病之间关系的现有证据。此外，我们还提到了（主要是病例报告）研究，这些研究表明粪便移植对某些疾病状态的临床结果有有益或不利的影响。如果这些发现能够在更大规模的随机对照双盲试验中得到证实，并且在干预前后还实施了肠道微生物组成的检测，那么粪便移植可能会为我们提供有关因果相关肠道微生物的新见解，这些见解可能成为人类疾病未来的诊断和治疗靶点。
