Dipartimento di Medicina Veterinaria, Università degli Studi di Bari, Valenzano, Bari, Italy.
Vet Parasitol. 2013 Nov 8;197(3-4):702-4. doi: 10.1016/j.vetpar.2013.05.012. Epub 2013 May 21.
Dirofilaria repens is one of the most widespread mosquito-borne filarioid responsible for infestations in dogs, usually characterized by nodules and other skin lesions. Additionally, the zoonotic potential of this nematode is of public health concern, given that D. repens has been often associated to human dirofilariosis in the Old World. In the present study, the therapeutic efficacy against D. repens microfilariae of a protocol based on doxycycline hyclate (Ronaxan(®), Merial), 10mg/kg every day for 30 days, and ivermectin (Cardotek 30(®), Merial), 6 μg/kg every 15 days for 6 months, was preliminarily investigated in two naturally infested dogs. Blood samples were collected every 30 days during 6 months of treatment and examined by a Knott's modified test and a duplex real-time PCR. The results here presented indicate that this therapeutic protocol, applied monthly, could be effective for treating microfilariaemia in dogs affected by subcutaneous dirofilariosis.
Repens 是一种最广泛传播的蚊媒丝状线虫，可引起犬类感染，通常表现为结节和其他皮肤损伤。此外，由于 Repens 线虫已在旧世界中经常与人类的犬心丝虫病相关联，因此该线虫的人畜共患病潜力引起了公共卫生关注。在本研究中，初步调查了一种基于盐酸多西环素（Ronaxan®，梅里亚），每天 10mg/kg，连续 30 天，以及伊维菌素（Cardotek 30®，梅里亚），每 15 天 6μg/kg，连续 6 个月的方案对两种自然感染的犬的 Repens 微丝蚴的治疗效果。在 6 个月的治疗期间，每 30 天采集一次血液样本，并通过诺特氏改良试验和双实时 PCR 进行检查。这里介绍的结果表明，这种每月应用的治疗方案可能对治疗患有皮下丝虫病的犬的微丝蚴血症有效。
