Department of Health Sciences, Faculty of Science, University of Mauritius, Reduit, Mauritius.
Asian Pac J Trop Med. 2013 Jul;6(7):561-9. doi: 10.1016/S1995-7645(13)60097-8.
To determine the contribution of total phenolic content (TPC) in glycation inhibitory activity of common tropical medicinal food and spices with potential antioxidative properties.
In vitro glucose-bovine serum albumin (BSA) assay was used. Ethanolic extracts of ten common household condiments/herbs (Allium sativum, Zingiber officinale, Thymus vulgaris, Petroselinum crispum, Murraya koenigii Spreng, Mentha piperita L., Curcuma longa L., Allium cepa L., Allium fistulosum and Coriandrum sativum L.) were evaluated for antioxidative activity by 2,2-diphenyl-2-picrylhydrazyl (DPPH), and ferric reducing antioxidant power (FRAP) and the TPC, flavonoid and tannins content were determined.
Findings showed good correlation between TPC/DPPH (r = 0.8), TPC/FRAP (r = 0.8), TPC/anti-glycation (r = 0.9), DPPH/anti-glycation (r = 0.6), FRAP/anti-glycation (r = 0.9), Flavonoid/anti-glycation (r = 0.7) and Tannins/anti-glycation (r = 0.8) and relatively fair correlation for TPC/Flavonoids (r = 0.5) and TPC/Tannins (r = 0.5). Results imply that these plants are potential sources of natural antioxidants which have free radical scavenging activity and might be used for reducing oxidative stress.
The positive glycation inhibitory and antioxidative activities of these tropical herbs suggest a possible role in targeting ageing, diabetic complications and oxidative stress related diseases.
确定具有潜在抗氧化特性的常见热带药用食品和香料中总酚含量（TPC）对糖基化抑制活性的贡献。
采用体外葡萄糖-牛血清白蛋白（BSA）测定法。评估了十种常见家庭调味品/草药（大蒜、生姜、普通麝香草、皱叶欧芹、金橘、胡椒薄荷、姜黄、洋葱、葱和芫荽）的乙醇提取物的抗氧化活性，通过 2,2-二苯基-2-苦基肼（DPPH）和铁还原抗氧化能力（FRAP）以及 TPC、类黄酮和单宁含量进行评估。
研究结果表明 TPC/DPPH（r = 0.8）、TPC/FRAP（r = 0.8）、TPC/抗糖基化（r = 0.9）、DPPH/抗糖基化（r = 0.6）、FRAP/抗糖基化（r = 0.9）、类黄酮/抗糖基化（r = 0.7）和单宁/抗糖基化（r = 0.8）之间存在良好的相关性，而 TPC/类黄酮（r = 0.5）和 TPC/单宁（r = 0.5）之间的相关性则相对较好。这些结果表明，这些植物是天然抗氧化剂的潜在来源，具有自由基清除活性，可能用于减少氧化应激。
这些热带草药的积极糖基化抑制和抗氧化活性表明它们可能在针对衰老、糖尿病并发症和与氧化应激相关的疾病方面发挥作用。
