Roudbari Mozhgan, Barzegar Mohsen, Sahari Mohammad Ali
Department of Food Science and Technology, Faculty of Agriculture Tarbiat Modares University Tehran Iran.
Food Sci Nutr. 2024 Feb 20;12(5):3688-3695. doi: 10.1002/fsn3.4039. eCollection 2024 May.
Advanced glycation end products (AGEs) are formed in the final step of the nonenzymatic Maillard reaction, which can contribute to various health problems such as diabetes mellitus, renal failure, and chronic inflammation. Bioactive compounds with antiglycation properties have the potential to inhibit AGE-related diseases. This study investigated the antiglycation potential of pistachio green hull (PGH) and pomegranate peel (PP) extracts, which are polyphenol-rich agro-residues, against fluorescent AGE formation and compared the results with pyridoxine (vitamin B6), metformin, and EDTA (as usual chemical antiglycation agents). The results showed that PGH and PP effectively inhibited the formation of AGEs in bovine serum albumin-glucose (BSA-Glu) and BSA-fructose (BSA-Fru) with antiglycation activities ranging from 92% to 97%. PP extract (with an IC of 94 mg ml) had a greater antiglycation ability than PGH extract (with an IC of 142 mg ml). Also, results indicated that the antiglycation activities of the extracts were comparable to that of pyridoxine, and higher than metformin and EDTA. These findings suggest that the two studied extracts can be used for sustainable production of high-added-value food products with a positive effect on consumers' health.
晚期糖基化终产物（AGEs）在非酶促美拉德反应的最后一步形成，这可能导致各种健康问题，如糖尿病、肾衰竭和慢性炎症。具有抗糖基化特性的生物活性化合物有可能抑制与AGE相关的疾病。本研究调查了富含多酚的农业废弃物开心果绿壳（PGH）和石榴皮（PP）提取物对荧光AGE形成的抗糖基化潜力，并将结果与吡哆醇（维生素B6）、二甲双胍和EDTA（作为常用的化学抗糖基化剂）进行比较。结果表明，PGH和PP能有效抑制牛血清白蛋白-葡萄糖（BSA-Glu）和牛血清白蛋白-果糖（BSA-Fru）中AGEs的形成，抗糖基化活性范围为92%至97%。PP提取物（IC为94 mg ml）的抗糖基化能力比PGH提取物（IC为142 mg ml）更强。此外，结果表明提取物的抗糖基化活性与吡哆醇相当，高于二甲双胍和EDTA。这些发现表明，所研究的两种提取物可用于可持续生产对消费者健康有积极影响的高附加值食品。
