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川续断科植物及其中的抗菌活性成分

Constituents of Caryopteris incana and their antibacterial activity.

机构信息

Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-Cho, Tokushima, 770-8514, Japan,

出版信息

J Nat Med. 2014 Jan;68(1):231-5. doi: 10.1007/s11418-013-0785-9. Epub 2013 Jun 16.

Abstract

Two new compounds named caryocanolide (1), and caryocanoside A (2), together with nine known compounds (3-11) were isolated from the whole plant of Caryopteris incana. These structures were determined mainly on the basis of 2D nuclear magnetic resonance and high resolution fast atom bombardment mass spectroscopy data. Furthermore, the isolated compounds (1, 2, 4-11) were tested for their antibacterial activity. Compound 1 exhibited moderate antimicrobial activity against Bacillus subtilis with a minimum inhibitory concentration value of 35.7 μM.

摘要

从贯叶连翘全株中分离得到两个新化合物命名为贯叶酮(1)和贯叶糖苷 A(2),以及 9 个已知化合物(3-11)。这些结构主要是根据二维核磁共振和高分辨快速原子轰击质谱数据确定的。此外,对分离得到的化合物(1、2、4-11)进行了抗菌活性测试。化合物 1 对枯草芽孢杆菌显示出中等的抗菌活性,最小抑菌浓度值为 35.7 μM。

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