Carley A Gomez-Meade, Adriana Carrillo, Division of Pediatric Endocrinology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL 33130, United States.
World J Diabetes. 2013 Jun 15;4(3):64-9. doi: 10.4239/wjd.v4.i3.64.
To examine the effect of gastric bypass surgery on cardiometabolic health among women with polycystic ovarian syndrome (PCOS).
Retrospective medical chart review identified women (n = 389) with PCOS who underwent Roux-en-Y gastric bypass surgery from 2001-2009 in one surgical practice. Separate repeated measures linear mixed models were fit using the MIXED procedure to assess mean change in cardiometabolic disease risk factors from before to 1-year after surgery and were evaluated by ethnicity [Hispanic, non-Hispanic black (NHB) and white (NHW)].
The majority of the sample was Hispanic (66%, 25% NHB, 9% NHW). Mean body mass index significantly improved 1 year post-surgery for all ethnic groups (45.5 to 35.5 kg/m(2) for Hispanics, 46.8 to 37.7 kg/m(2) for NHB and 45.7 to 36.7 kg/m(2) for NHW, P < 0.001). Among Hispanic women mean total cholesterol (198.1 to 160.2 mg/dL), low-density lipoproteins (LDL) cholesterol (120.9 to 91.0 mg/dL), triglycerides (148.6 to 104.8 mg/dL), hemoglobin A1c (6.2% to 5.6%), alanine aminotransferase (28.1 to 23.0 U/L) and aspartate aminotransferase (23.5 to 21.6 U/L) decreased significantly (P < 0.001). Among NHB, mean total cholesterol (184.5 to 154.7 mg/dL), LDL cholesterol (111.7 to 88.9 mg/dL) and triglycerides (99.7 to 70.0 mg/dL) decreased significantly (P < 0.05). Among NHW, mean total cholesterol (200.9 to 172.8 mg/dL) and LDL cholesterol (124.2 to 96.6 mg/dL), decreased significantly (P < 0.05). Pairwise ethnic group comparisons of all cardiometabolic outcomes adjusted for age and type of surgery before and 1 year after surgery showed no statistical difference between the three groups for any outcome.
Cardiometabolic disease risk improvements vary by ethnicity and obesity may impact glucose tolerance and liver function changes more in Hispanic women with PCOS vs non-Hispanic women.
探讨胃旁路手术对多囊卵巢综合征（PCOS）女性心脏代谢健康的影响。
回顾性病历回顾分析了 2001 年至 2009 年期间在一家外科诊所接受 Roux-en-Y 胃旁路手术的 PCOS 女性（n=389）。使用 MIXED 过程分别拟合了单独的重复测量线性混合模型，以评估手术前后心脏代谢疾病风险因素的平均变化，并按种族[西班牙裔、非西班牙裔黑人（NHB）和白人（NHW）]进行评估。
大多数样本为西班牙裔（66%，25% NHB，9% NHW）。所有种族的体重指数在手术后 1 年均显著改善（西班牙裔从 45.5 降至 35.5kg/m²，NHB 从 46.8 降至 37.7kg/m²，NHW 从 45.7 降至 36.7kg/m²，P<0.001）。在西班牙裔女性中，总胆固醇（198.1 至 160.2mg/dL）、低密度脂蛋白胆固醇（120.9 至 91.0mg/dL）、甘油三酯（148.6 至 104.8mg/dL）、糖化血红蛋白（6.2%至 5.6%）、丙氨酸氨基转移酶（28.1 至 23.0U/L）和天冬氨酸氨基转移酶（23.5 至 21.6U/L）均显著降低（P<0.001）。在 NHB 中，总胆固醇（184.5 至 154.7mg/dL）、低密度脂蛋白胆固醇（111.7 至 88.9mg/dL）和甘油三酯（99.7 至 70.0mg/dL）均显著降低（P<0.05）。在 NHW 中，总胆固醇（200.9 至 172.8mg/dL）和低密度脂蛋白胆固醇（124.2 至 96.6mg/dL）均显著降低（P<0.05）。手术前后按年龄和手术类型调整的所有心脏代谢结果的组间比较显示，三组之间在任何结果上均无统计学差异。
心脏代谢疾病风险的改善因种族而异，肥胖可能会影响西班牙裔 PCOS 女性的葡萄糖耐量和肝功能变化，而非西班牙裔女性则不然。
