Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, J. Paul Sticht Center on Aging, Wake Forest University, Winston-Salem, North Carolina 27157, USA.
J Am Geriatr Soc. 2013 Jul;61(7):1089-94. doi: 10.1111/jgs.12321. Epub 2013 Jun 17.
To determine the independent effect of long-term physical activity (PA) and the combined effects of long-term PA and weight loss (WL) on inflammation in overweight and obese older adults.
Eighteen-month randomized, controlled trial.
The community infrastructure of cooperative extension centers.
Overweight and obese (body mass index >28.0 kg/m(2) ) community-dwelling men and women aged 60 to 79 at risk for cardiovascular disease (CVD).
Physical activity + weight loss (PA + WL) (n = 98), PA only (n = 97), or successful aging (SA) health education (n = 93) intervention.
Biomarkers of inflammation (adiponectin, leptin, high-sensitivity interleukin (hsIL)-6, IL-6sR, IL-8, and soluble tumor necrosis factor receptor 1) were measured at baseline and 6 and 18 months.
After adjustment for baseline biomarker, wave, sex, and visit, leptin and hsIL-6 showed a significant intervention effect. Specifically, leptin was significantly lower in the PA + WL group (21.3 ng/mL, 95% confidence interval (CI) = 19.7-22.9 ng/mL) than in the PA (29.3 ng/mL, 95% CI = 26.9-31.8 ng/mL) or SA (30.3 ng/mL, 95% CI = 27.9-32.8 ng/mL) group (both P < .001), and hsIL-6 was significantly lower in the PA + WL group (2.1 pg/mL, 95% CI = 1.9-2.3 pg/mL) than in the PA (2.5 pg/mL, 95% CI = 2.3-2.7 pg/mL) or SA (2.4 pg/mL, 95% CI = 2.2-2.6 pg/mL) group (P = .02).
Addition of dietary-induced WL to PA reduced leptin and hsIL-6 more than PA alone and more than a SA intervention in older adults at risk for CVD. Results suggest that WL, rather than increased PA, is the lifestyle factor primarily responsible for improvement in the inflammatory profile.
确定长期体力活动（PA）的独立作用，以及长期 PA 与减肥（WL）相结合对超重和肥胖老年人群炎症的综合影响。
为期 18 个月的随机对照试验。
合作推广中心的社区基础设施。
超重和肥胖（身体质量指数>28.0kg/m2）、有心血管疾病（CVD）风险的社区居住的 60 至 79 岁男女。
体力活动+减肥（PA+WL）（n=98）、仅体力活动（n=97）或成功老龄化（SA）健康教育（n=93）干预。
炎症生物标志物（脂联素、瘦素、高敏白细胞介素（hsIL）-6、IL-6sR、IL-8 和可溶性肿瘤坏死因子受体 1）在基线和 6 个月和 18 个月时进行测量。
在调整基线生物标志物、波次、性别和访视后，瘦素和 hsIL-6 显示出显著的干预效果。具体来说，PA+WL 组的瘦素明显低于 PA 组（21.3ng/mL，95%置信区间（CI）=19.7-22.9ng/mL）（P<0.001）和 SA 组（30.3ng/mL，95%CI=27.9-32.8ng/mL），而 hsIL-6 在 PA+WL 组（2.1pg/mL，95%CI=1.9-2.3pg/mL）明显低于 PA 组（2.5pg/mL，95%CI=2.3-2.7pg/mL）（P=0.02）或 SA 组（2.4pg/mL，95%CI=2.2-2.6pg/mL）。
与单独进行 PA 相比，饮食诱导的 WL 与 PA 联合应用能更显著地降低瘦素和 hsIL-6，而且比 SA 干预更有效。结果表明，改善炎症特征的主要生活方式因素是 WL，而不是增加 PA。
