Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran.
Psychiatry Res. 2013 Nov 30;210(1):263-7. doi: 10.1016/j.psychres.2013.05.027. Epub 2013 Jun 14.
Amphetamine abuse may lead to a psychotic state, its symptomatology being very similar to what is seen in paranoid schizophrenia. Failure of attentional inhibition of irrelevant information is thought to be associated with the psychotic symptoms in schizophrenia. Negative priming (NP) paradigm is believed to measure this impairment. Several studies have shown impaired NP in schizophrenia. In the present study a spatial NP task was used to assess attentional inhibition in a group of amphetamine-induced psychosis patients. Nineteen patients with amphetamine-induced psychotic disorder and 20 healthy subjects participated in this study. Severity of psychotic symptoms was measured prior to testing using the Brief Psychiatric Rating Scale (BPRS). Patients showed no deficit in NP, and the amount of their NP effect was not significantly different from healthy subjects. Besides, we did not find any correlation between the amount of NP effect and severity of symptoms. Our results may indicate that cognitive mechanisms underlying NP might not be affected in amphetamine psychosis.
苯丙胺滥用可能导致精神病状态，其症状与偏执型精神分裂症所见非常相似。注意力对无关信息的抑制失败被认为与精神分裂症的精神病症状有关。负启动（NP）范式被认为可以衡量这种损伤。几项研究表明精神分裂症中存在 NP 损伤。在本研究中，使用空间 NP 任务来评估一组苯丙胺引起的精神病患者的注意力抑制。19 名患有苯丙胺引起的精神病障碍的患者和 20 名健康受试者参加了这项研究。在测试前使用简明精神病评定量表（BPRS）测量精神病症状的严重程度。患者在 NP 方面没有表现出缺陷，他们的 NP 效应量与健康受试者没有显著差异。此外，我们没有发现 NP 效应量与症状严重程度之间存在任何相关性。我们的结果可能表明，NP 背后的认知机制在苯丙胺精神病中可能不受影响。
