Lv Chong-Ning, Li Yan-Jiao, Wang Jing, Qin Ru-Lan, Lei Tian-Li, Lu Jin-Cai
a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
b Department of Science of Chinese Medicinal Material Resources, School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
J Asian Nat Prod Res. 2016 Jul;18(7):648-55. doi: 10.1080/10286020.2016.1142974. Epub 2016 Mar 15.
Phytochemical investigation of the 70% EtOH extract of the rhizome of Anemone amurensis led to the isolation of two new oleanane-type triterpenoid saponins 1 and 2. Their structures were elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR data, and HR-ESI-MS. Compounds 1 and 2 were tested for cytotoxicities against two human cancer cell lines (A549 and Hep-G2). Compound 2 showed potent cytotoxicity with IC50 values of 38.53 and 66.17 μM, respectively, while compound 1 with IC50 > 100 μM.
对毛茛根茎70%乙醇提取物进行植物化学研究，分离得到两种新的齐墩果烷型三萜皂苷1和2。基于化学和光谱分析，包括一维、二维核磁共振数据以及高分辨电喷雾电离质谱，阐明了它们的结构。测试了化合物1和2对两种人类癌细胞系（A549和Hep-G2）的细胞毒性。化合物2表现出较强的细胞毒性，其IC50值分别为38.53和66.17 μM，而化合物1的IC50>100 μM。
