Dudani Sharmila J, Kalhan Shivani, Sharma Sonia P
Department of Pathology, Army College of Medical Sciences, Delhi Cantt., New Delhi, India.
Int J Appl Basic Med Res. 2011 Jul;1(2):71-4. doi: 10.4103/2229-516X.91146.
Multiple sclerosis (MS) is thought to arise due to an interplay of genetic and environmental risk factors. Vitamin D, besides maintaining bone health and calcium metabolism, is thought to play an immunomodulatory role in the central nervous system. Studies have shown that patients with the highest level of Vitamin D (99-152 nmol/l) had a significantly lower risk of MS than the subgroup with the lowest levels (15-63 nmol/l). Furthermore, populations having a high oral intake of vitamin D had a decreased risk of MS. Hypovitaminosis D is one of the environmental risk factors for MS based on numerous physiological, experimental and epidemiologic data, which can be corrected to provide an effective therapeutic option for this debilitating disease.
多发性硬化症（MS）被认为是由遗传和环境风险因素相互作用引起的。维生素D除了维持骨骼健康和钙代谢外，还被认为在中枢神经系统中发挥免疫调节作用。研究表明，维生素D水平最高（99-152 nmol/l）的患者患MS的风险明显低于水平最低（15-63 nmol/l）的亚组。此外，维生素D口服摄入量高的人群患MS的风险降低。基于大量生理、实验和流行病学数据，维生素D缺乏是MS的环境风险因素之一，可通过纠正维生素D缺乏为这种使人衰弱的疾病提供有效的治疗选择。
