常驻病毒及其与免疫系统的相互作用。

Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Nat Immunol. 2013 Jul;14(7):654-9. doi: 10.1038/ni.2614.

The human body is colonized with a diverse resident microflora that includes viruses. Recent studies of metagenomes have begun to characterize the composition of the human 'virobiota' and its associated genes (the 'virome'), and have fostered the emerging field of host-virobiota interactions. In this Perspective, we explore how resident viruses interact with the immune system. We review recent findings that highlight the role of the immune system in shaping the composition of the virobiota and consider how resident viruses may impact host immunity. Finally, we discuss the implications of virobiota-immune system interactions for human health.

人体定植着丰富多样的常驻微生物菌群，其中包括病毒。最近对宏基因组的研究开始描绘人类“病毒组”及其相关基因（即“病毒组”）的组成，并推动了宿主-病毒组相互作用这一新兴领域的发展。在本观点文章中，我们探讨了常驻病毒与免疫系统的相互作用。我们回顾了最近的发现，这些发现强调了免疫系统在塑造病毒组组成方面的作用，并考虑了常驻病毒如何影响宿主免疫。最后，我们讨论了病毒组-免疫系统相互作用对人类健康的影响。