瘤内血管密度作为头颈部鳞状细胞癌的预后因素：一项文献荟萃分析

Intratumoral vessel density as prognostic factors in head and neck squamous cell carcinoma: a meta-analysis of literature.

作者信息

Yu Min, Liu Lei, Liang Chunshui, Li Ping, Ma Xuelei, Zhang Qiongwen, Wei Yuquan

机构信息

Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.

出版信息

Head Neck. 2014 Apr;36(4):596-602. doi: 10.1002/hed.23301. Epub 2013 Jun 18.

DOI:10.1002/hed.23301

PMID:23780885

Abstract

BACKGROUND

The purpose of this study was to comprehensively and quantitatively summarize the prognostic value of microvessel density (MVD) and lymphatic vessel density (LVD) for the survival of patients with head and neck squamous cell carcinoma (HNSCC).

METHODS

Relevant literatures were identified using Medline and EMBASE. A meta-analysis was performed to clarify the prognostic role of MVD and LVD.

RESULTS

A total of 18 articles (13 for MVD and 5 for LVD; n = 1279 and n = 408) were pooled for the global meta-analysis. The mortality was 1.23-fold higher for patients whose MVD counts were above the cutoff (risk ratio [RR], 1.23; 95% confidence interval [CI], 0.99-1.52), compared with those below it, and this result was on a borderline (p = .06). The mortality of patients with high LVD counts was 2.07-fold higher (RR, 2.07; 95% CI, 1.16-3.71; p = .01).

CONCLUSION

High counts of LVD, not MVD, are associated with worse 5-year overall survival (OS) in patients with HNSCC.

摘要

背景

本研究旨在全面且定量地总结微血管密度（MVD）和淋巴管密度（LVD）对头颈部鳞状细胞癌（HNSCC）患者生存的预后价值。

方法

使用Medline和EMBASE检索相关文献。进行荟萃分析以阐明MVD和LVD的预后作用。

结果

总共纳入18篇文章（13篇关于MVD，5篇关于LVD；n = 1279和n = 408）进行全球荟萃分析。MVD计数高于临界值的患者死亡率比低于临界值的患者高1.23倍（风险比[RR]，1.23；95%置信区间[CI]，0.99 - 1.52），该结果处于临界状态（p = 0.06）。LVD计数高的患者死亡率高2.07倍（RR，2.07；95% CI，1.16 - 3.71；p = 0.01）。