Oscar-Berman M, Hancock M, Mildworf B, Hutner N, Weber D A
Division of Psychiatry, Boston University School of Medicine, Massachusetts.
Alcohol Clin Exp Res. 1990 Jun;14(3):383-93. doi: 10.1111/j.1530-0277.1990.tb00491.x.
The ability to identify and recognize emotional materials was studied in 10 male alcoholic Korsakoff patients, 27 male non-Korsakoff alcoholics, and 31 male nonalcoholic controls, across a wide age range (23 to 77 years). Stimulus materials were presented in two sensory modalities; the materials were photographs of faces expressing one of four emotions (happy, sad, angry, or neutral), and recordings of sentences with emotional intonations or semantic meanings expressing the same four emotions. Results of the experiments showed consistently severe deficits in emotional functions in the Korsakoff patients, but only minor alterations in the non-Korsakoff alcoholics. Older subjects, whether or not they had a history of alcoholism, also exhibited significant deficits on most of the tasks. Results of the study did not provide strong support for the premature aging hypothesis of alcoholism, which suggests that alcoholism accelerates aging, beginning either at the onset of heavy drinking early in adult life, or later in life after the normal manifestations of aging have begun to appear. Results are related to brain mechanisms in emotional perception and memory functions.
在年龄跨度较大（23至77岁）的10名男性酒精性柯萨可夫综合征患者、27名男性非柯萨可夫综合征酗酒者和31名男性非酗酒对照者中，研究了识别和辨认情感材料的能力。刺激材料通过两种感官形式呈现；材料包括表达四种情绪（快乐、悲伤、愤怒或中性）之一的面部照片，以及带有表达相同四种情绪的情感语调或语义的句子录音。实验结果显示，柯萨可夫综合征患者在情感功能方面始终存在严重缺陷，但非柯萨可夫综合征酗酒者仅有轻微改变。年龄较大的受试者，无论是否有酗酒史，在大多数任务中也表现出显著缺陷。该研究结果并未为酗酒的早衰假说提供有力支持，该假说认为酗酒会加速衰老，要么在成年早期开始大量饮酒时就开始加速，要么在衰老的正常表现开始出现后的晚年开始加速。研究结果与情感感知和记忆功能中的脑机制有关。
