Ryan C, Butters N
Alcohol Clin Exp Res. 1980 Apr;4(2):190-8. doi: 10.1111/j.1530-0277.1980.tb05634.x.
A battery of challening tests was used to assess learning ability and short-term memory in groups of detoxified chronic alcoholics with and without complaints of memory impairment, alcoholic Korsakoff patients, and nonalcoholic controls. While alcoholics without memory complaints did not differ from controls on standardized clinical memory tests, their performance was significantly impaired on our more demanding experimental tests. In contrast, the performance of alcoholics reporting memory complaints was impaired, relative to the other alcoholics, on both clinical and experimental memory tests, overlapping that of the alcoholig Korsakoff patients. These results are consonant with Ryback's continuum-of-impairment hypothesis.
一组具有挑战性的测试被用于评估戒酒的慢性酒精中毒患者(有或没有记忆障碍主诉)、酒精性科萨科夫综合征患者以及非酒精性对照人群的学习能力和短期记忆。虽然没有记忆障碍主诉的酒精中毒患者在标准化临床记忆测试中与对照组没有差异,但在我们要求更高的实验测试中,他们的表现明显受损。相比之下,报告有记忆障碍主诉的酒精中毒患者在临床和实验记忆测试中的表现相对于其他酒精中毒患者均受损,与酒精性科萨科夫综合征患者的表现重叠。这些结果与莱巴克的损伤连续体假说一致。