Li Chenguang, Wang Changli
Department of Lung Cancer, Tianjin Lung Cancer Center, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China.
Tumour Biol. 2013 Dec;34(6):3477-82. doi: 10.1007/s13277-013-0925-6. Epub 2013 Jun 20.
Interleukin 1, beta (IL1B) plays a key role in mediating acute and chronic inflammation, which is further correlated with lung carcinogenesis. Several polymorphisms on IL1B gene have been identified, and a series of epidemiological studies have examined the association between IL1B polymorphisms and lung cancer risk. However, these findings are inconclusive. To derive a precise estimation of the relationship, a meta-analysis was performed. We summarized 12 eligible publications on three commonly studied IL1B polymorphisms (i.e., -31 T/C, -511 T/C, and +3954 C/T) by searching electronic databases. Combined odds ratio (OR) with 95% confidence interval (CI) was calculated to assess the strength of association between them. Heterogeneity and publication bias were also assessed. We observed a significant association between IL1B polymorphisms and lung cancer. For -31T/C, the overall OR (95% CI) of TT/TC versus CC was 1.23 (1.06-1.43). For +3954 C/T, the overall OR (95% CI) of CC versus TT and CC versus CT/TT were 0.92 (0.86-0.99) and 0.92 (0.86-0.99), respectively. In conclusion, this meta-analysis suggests that the IL1B -31 T/C and +3954 C/T polymorphisms are associated with lung cancer risk. However, larger number of samples and studies with homogeneous lung cancer patients are needed to confirm these findings.
白细胞介素1β（IL1B）在介导急性和慢性炎症中起关键作用，而炎症进一步与肺癌发生相关。已鉴定出IL1B基因上的几种多态性，并且一系列流行病学研究已考察了IL1B多态性与肺癌风险之间的关联。然而，这些发现尚无定论。为了精确估计二者关系，我们进行了一项荟萃分析。通过检索电子数据库，我们总结了关于三种常见研究的IL1B多态性（即-31 T/C、-511 T/C和+3954 C/T）的12篇合格出版物。计算合并优势比（OR）及95%置信区间（CI）以评估它们之间关联的强度。还评估了异质性和发表偏倚。我们观察到IL1B多态性与肺癌之间存在显著关联。对于-31T/C，TT/TC与CC相比的总体OR（95%CI）为1.23（1.06 - 1.43）。对于+3954 C/T，CC与TT相比以及CC与CT/TT相比的总体OR（95%CI）分别为0.92（0.86 - 0.99）和0.92（0.86 - 0.99）。总之，这项荟萃分析表明IL1B -31 T/C和+3954 C/T多态性与肺癌风险相关。然而，需要更多样本以及针对同质肺癌患者的研究来证实这些发现。
