具有季立体中心的功能化二苯并氮杂卓的对映选择性 C-H 芳基化策略。
Enantioselective C-H arylation strategy for functionalized dibenzazepinones with quaternary stereocenters.
机构信息
Laboratory of Asymmetric Catalysis and Synthesis, EPFL SB ISIC LCSA, BCH 4305, 1015 Lausanne, Switzerland.
出版信息
Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7865-8. doi: 10.1002/anie.201303816. Epub 2013 Jun 19.
PMID:23784692
Abstract
Tada! Highly functionalized chiral dibenzazepinones are obtained by a mild palladium(0)-catalyzed enantioselective C-H arylation with excellent selectivities by using simple taddol phosphoramidite ligands. The amide tether allows exclusive regioselectivity through a rare eight-membered palladacycle intermediate.
摘要
太棒了！通过使用简单的手性螺环磷酰胺配体，温和的钯(0)催化对映选择性 C-H 芳基化反应，得到了高功能化的手性二苯并氮杂卓酮，具有优异的选择性。酰胺键允许通过罕见的八元钯环中间体进行独特的区域选择性。
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