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Br J Clin Pharmacol. 1984 Dec;18(6):873-7. doi: 10.1111/j.1365-2125.1984.tb02558.x.
2
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Effects of age and antiepileptic drugs on plasma levels and kinetics of clobazam and N-desmethylclobazam.年龄和抗癫痫药物对氯巴占及N-去甲基氯巴占血浆水平和药代动力学的影响。
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Interactions of clobazam with conventional antiepileptics in children.氯巴占与儿童常用抗癫痫药物的相互作用。
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Clinically significant pharmacokinetic drug interactions with carbamazepine. An update.卡马西平具有临床意义的药代动力学药物相互作用。最新进展。
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N-desmethylclobazam: a possible alternative to clobazam in the treatment of refractory epilepsy?N-去甲基氯巴占：治疗难治性癫痫时氯巴占的一种可能替代药物？
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10
The effect of cimetidine on the single dose pharmacokinetics of oral clobazam and N-desmethylclobazam.西咪替丁对口服氯巴占及N-去甲基氯巴占单剂量药代动力学的影响。
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本文引用的文献

1
Clobazam plasma concentrations: pharmacokinetic study in healthy volunteers and data in epileptic patients.氯巴占血浆浓度：健康志愿者的药代动力学研究及癫痫患者的数据
Br J Clin Pharmacol. 1981 Jun;11(6):619-22. doi: 10.1111/j.1365-2125.1981.tb01180.x.
2
Clobazam kinetics: intrasubject variability and effect of food on adsorption.
J Clin Pharmacol. 1982 Jan;22(1):69-73. doi: 10.1002/j.1552-4604.1982.tb05711.x.
3
Pharmacokinetics of diazepam in epileptic patients and normal volunteers following intravenous administration.癫痫患者和正常志愿者静脉注射地西泮后的药代动力学
Br J Clin Pharmacol. 1981 Dec;12(6):841-4. doi: 10.1111/j.1365-2125.1981.tb01317.x.
4
Clobazam as adjunctive treatment in refractory epilepsy.氯巴占作为难治性癫痫的辅助治疗药物。
Br Med J (Clin Res Ed). 1983 Apr 16;286(6373):1246-7. doi: 10.1136/bmj.286.6373.1246.
5
Effect of phenobarbital on the in vitro metabolism of diazepam in several animal species.
Biochem Pharmacol. 1970 May;19(5):1771-6. doi: 10.1016/0006-2952(70)90169-3.
6
Interindividual differences in rates of drug oxidation in man.人类药物氧化速率的个体差异。
Drug Metab Dispos. 1973 Jan-Feb;1(1):411-7.
7
Assessment of antipyrine kinetics by measurement in saliva.通过唾液测量评估安替比林动力学。
Br J Clin Pharmacol. 1976 Apr;3(2):321-5. doi: 10.1111/j.1365-2125.1976.tb00610.x.
8
Time-course of interaction between carbamazepine and clonazepam in normal man.
Clin Pharmacol Ther. 1978 Sep;24(3):316-23. doi: 10.1002/cpt1978243316.
9
The effect of enzyme induction on diazepam metabolism in man.酶诱导对人体地西泮代谢的影响。
Br J Clin Pharmacol. 1979 Dec;8(6):557-63. doi: 10.1111/j.1365-2125.1979.tb01044.x.
10
Pharmacology of anti-anxiety drugs with special reference to clobazam.抗焦虑药物的药理学，特别提及氯巴占。
Br J Clin Pharmacol. 1979;7 Suppl 1(Suppl 1):7S-15S.

氯巴占在正常志愿者和癫痫患者中的单剂量药代动力学研究。

Single dose pharmacokinetic study of clobazam in normal volunteers and epileptic patients.

作者信息

Jawad S, Richens A, Oxley J

出版信息

Br J Clin Pharmacol. 1984 Dec;18(6):873-7. doi: 10.1111/j.1365-2125.1984.tb02558.x.

DOI:10.1111/j.1365-2125.1984.tb02558.x
PMID:6529527
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1463679/
Abstract

The pharmacokinetics of clobazam were studied in six healthy volunteers and six age and sex matched enzyme-induced epileptic patients. In the epileptic patients the area under the plasma concentration-time curve for clobazam was significantly smaller and the area under the plasma concentration-time curve for N-desmethylclobazam was significantly greater than in the healthy volunteers. Plasma N-desmethylclobazam concentrations were found to be much higher than those of clobazam in the epileptic patients, raising the possibility that the antiepileptic properties of clobazam are to be attributed more to its metabolite than the parent drug.

摘要

在6名健康志愿者以及6名年龄和性别匹配的酶诱导型癫痫患者中研究了氯巴占的药代动力学。在癫痫患者中，氯巴占的血浆浓度-时间曲线下面积显著较小，而N-去甲基氯巴占的血浆浓度-时间曲线下面积显著大于健康志愿者。发现在癫痫患者中血浆N-去甲基氯巴占浓度远高于氯巴占浓度，这增加了氯巴占的抗癫痫特性更多归因于其代谢物而非母体药物的可能性。