氯巴占在正常志愿者和癫痫患者中的单剂量药代动力学研究。
Single dose pharmacokinetic study of clobazam in normal volunteers and epileptic patients.
作者信息
Jawad S, Richens A, Oxley J
出版信息
Br J Clin Pharmacol. 1984 Dec;18(6):873-7. doi: 10.1111/j.1365-2125.1984.tb02558.x.
Abstract
The pharmacokinetics of clobazam were studied in six healthy volunteers and six age and sex matched enzyme-induced epileptic patients. In the epileptic patients the area under the plasma concentration-time curve for clobazam was significantly smaller and the area under the plasma concentration-time curve for N-desmethylclobazam was significantly greater than in the healthy volunteers. Plasma N-desmethylclobazam concentrations were found to be much higher than those of clobazam in the epileptic patients, raising the possibility that the antiepileptic properties of clobazam are to be attributed more to its metabolite than the parent drug.
摘要
在6名健康志愿者以及6名年龄和性别匹配的酶诱导型癫痫患者中研究了氯巴占的药代动力学。在癫痫患者中，氯巴占的血浆浓度-时间曲线下面积显著较小，而N-去甲基氯巴占的血浆浓度-时间曲线下面积显著大于健康志愿者。发现在癫痫患者中血浆N-去甲基氯巴占浓度远高于氯巴占浓度，这增加了氯巴占的抗癫痫特性更多归因于其代谢物而非母体药物的可能性。
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