Pacholczyk Barbara, Fabiańska Anna, Kusińska Renata, Potemski Piotr, Kordek Radzisław, Jankowski Stefan
Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, Poland.
Contemp Oncol (Pozn). 2012;16(4):290-4. doi: 10.5114/wo.2012.30056. Epub 2012 Sep 29.
The personalized approach in cancer treatment stimulates the search for new analytical techniques, including spectroscopic methods such as Raman spectroscopy, mass spectrometry MALDI (matrix-assisted laser desorption/ionization) imaging and high-resolution magic angle spinning nuclear magnetic resonance (HR MAS NMR). The purpose of these studies is determination of metabolic profiles of cancer tissues, and their application in diagnostics and therapy of cancers. The review is mainly focused on application of HR MAS NMR technique. Qualitative and quantitative analysis of metabolites by means of this method is described for breast cancer tissues. In the near future HR MAS NMR in vitro studies of metabolic profiles combined with in vivo studies using MRI scanners may be applied as a new diagnostic tool.
癌症治疗中的个性化方法推动了对新分析技术的探索，包括光谱方法，如拉曼光谱、基质辅助激光解吸/电离（MALDI）质谱成像和高分辨率魔角旋转核磁共振（HR MAS NMR）。这些研究的目的是确定癌组织的代谢谱，并将其应用于癌症的诊断和治疗。本综述主要聚焦于HR MAS NMR技术的应用。本文描述了利用该方法对乳腺癌组织中的代谢物进行定性和定量分析。在不久的将来，结合使用MRI扫描仪进行的体内研究，对代谢谱进行HR MAS NMR体外研究可能会作为一种新的诊断工具得到应用。
