Department of Epizootiology and Clinic of Infectious Diseases, University of Life Sciences, Głęboka St. 30, 20-612 Lublin, Poland.
Res Vet Sci. 2013 Oct;95(2):316-20. doi: 10.1016/j.rvsc.2013.05.010. Epub 2013 Jun 19.
Anaplasma phagocytophilum is an emerging pathogen of horses that is transmitted by Ixodid ticks. Recent studies suggest that multiple strains of A. phagocytophilum may be circulating in wild and domestic animal populations, and these strains may have differential host tropisms and pathogenicity. The organism infects and survives within neutrophils. Co-infections with other tick-borne pathogens may occur, especially Borrelia burgdorferi. A. phagocytophilum causes an acute febrile illness in horses with lethargy, inappetence, lameness and hemorrhages. Diagnosis is based on finding morulae within granulocytes in the peripheral blood, and detection of the DNA of A. phagocytophilum using specific polymerase chain reaction assays. Most reports suggesting that anaplasmosis is a self-limiting disease that responds well to a tetracycline therapy.
嗜吞噬细胞无形体是一种新兴的马类病原体，通过硬蜱传播。最近的研究表明，多种嗜吞噬细胞无形体菌株可能在野生动物和家养动物群体中传播，这些菌株可能具有不同的宿主嗜性和致病性。该病原体感染并存活于中性粒细胞内。可能与其他蜱传病原体发生合并感染，特别是伯氏疏螺旋体。嗜吞噬细胞无形体引起马的急性发热性疾病，表现为嗜睡、食欲不振、跛行和出血。诊断基于在外周血的粒细胞中发现纳氏小体，并使用特定的聚合酶链反应检测嗜吞噬细胞无形体的 DNA。大多数报告表明，无形体病是一种自限性疾病，对四环素治疗反应良好。
