Sackler Institute of Psychobiological Research, Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, UK,
Cerebellum. 2013 Dec;12(6):882-91. doi: 10.1007/s12311-013-0497-4.
The cerebellum is highly sensitive to adverse environmental factors throughout the life span. Socioeconomic deprivation has been associated with greater inflammatory and cardiometabolic risk, and poor neurocognitive function. Given the increasing awareness of the association between early-life adversities on cerebellar structure, we aimed to explore the relationship between early life (ESES) and current socioeconomic status (CSES) and cerebellar volume. T1-weighted MRI was used to create models of cerebellar grey matter volumes in 42 adult neurologically healthy males selected from the Psychological, Social and Biological Determinants of Ill Health study. The relationship between potential risk factors, including ESES, CSES and cerebellar grey matter volumes were examined using multiple regression techniques. We also examined if greater multisystem physiological risk index-derived from inflammatory and cardiometabolic risk markers-mediated the relationship between socioeconomic status (SES) and cerebellar grey matter volume. Both ESES and CSES explained the greatest variance in cerebellar grey matter volume, with age and alcohol use as a covariate in the model. Low CSES explained additional significant variance to low ESES on grey matter decrease. The multisystem physiological risk index mediated the relationship between both early life and current SES and grey matter volume in cerebellum. In a randomly selected sample of neurologically healthy males, poorer socioeconomic status was associated with a smaller cerebellar volume. Early and current socioeconomic status and the multisystem physiological risk index also apparently influence cerebellar volume. These findings provide data on the relationship between socioeconomic deprivation and a brain region highly sensitive to environmental factors.
小脑在整个生命周期中对不利的环境因素高度敏感。社会经济剥夺与更高的炎症和心血管代谢风险以及较差的神经认知功能有关。鉴于人们越来越意识到早期逆境与小脑结构之间的关联，我们旨在探讨生命早期（ESES）和当前社会经济地位（CSES）与小脑体积之间的关系。使用 T1 加权 MRI 对来自心理、社会和生物决定因素健康研究的 42 名成年神经健康男性进行小脑灰质体积模型的创建。使用多元回归技术检查了包括 ESES、CSES 和小脑灰质体积在内的潜在风险因素之间的关系。我们还检查了多系统生理风险指数是否——炎症和心血管代谢风险标志物的综合指数——调节了社会经济地位（SES）和小脑灰质体积之间的关系。ESES 和 CSES 均能解释小脑灰质体积的最大方差，在模型中年龄和酒精使用作为协变量。低 CSES 解释了灰质减少中除低 ESES 之外的额外显著方差。多系统生理风险指数调节了生命早期和当前 SES 与小脑灰质体积之间的关系。在随机选择的一组神经健康男性中，较差的社会经济地位与小脑体积较小有关。早期和当前的社会经济地位以及多系统生理风险指数显然也会影响小脑体积。这些发现提供了关于社会经济剥夺与对环境因素高度敏感的大脑区域之间关系的数据。
