Voruz Philippe, Constantin Ioana Medeleine, Chassot Emilie, Thomasson Marine, Assal Frédéric, Péron Julie Anne
Clinical and Experimental Neuropsychology Laboratory, Faculty of Psychology, Geneva, Switzerland.
Neurosurgery Department, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
Cerebellum. 2025 Jan 7;24(1):27. doi: 10.1007/s12311-024-01775-x.
While deficits in episodic memory have been noted following cerebellar damage, there is a lack of research systematically exploring the socio-demographic and cognitive profiles of patients with such impairments. This study aimed to differentiate between chronic-phase cerebellar stroke patients with and without verbal episodic memory deficits, and to determine whether those with deficits exhibit distinct socio-demographic and clinical profiles, thereby identifying potential factors associated with these impairments. Data from 15 cerebellar stroke patients in the CEREBEMO cohort were analyzed, with participants categorized into two groups based on verbal episodic memory performance: deficits (n = 8) and no deficits (n = 7). Statistical analyses, including Generalized Linear Mixed Models and Chi-Squared tests, compared socio-demographic and neuropsychological variables between the groups. Significant differences were observed in socio-educational levels, with a higher proportion of patients with memory deficits at intermediate education levels. Moreover, patients with memory deficits performed worse on the Montreal Cognitive Assessment and the Trail Making Test, indicating overall lower cognitive efficiency and slower processing speed. Post-hoc analysis showed that, despite the limited sample size, our sample effectively detected a significant difference between the two groups with high statistical power. These findings highlight potential socio-educational and cognitive factors associated with memory impairments following cerebellar stroke.
虽然小脑损伤后已发现情景记忆存在缺陷，但缺乏系统探索此类损伤患者的社会人口统计学和认知特征的研究。本研究旨在区分有和没有言语情景记忆缺陷的慢性期小脑中风患者，并确定有缺陷的患者是否表现出独特的社会人口统计学和临床特征，从而识别与这些损伤相关的潜在因素。对CEREBEMO队列中15名小脑中风患者的数据进行了分析，根据言语情景记忆表现将参与者分为两组：有缺陷组（n = 8）和无缺陷组（n = 7）。包括广义线性混合模型和卡方检验在内的统计分析比较了两组之间的社会人口统计学和神经心理学变量。在社会教育水平上观察到显著差异，中等教育水平的记忆缺陷患者比例更高。此外，记忆缺陷患者在蒙特利尔认知评估和连线测验中的表现更差，表明总体认知效率较低且处理速度较慢。事后分析表明，尽管样本量有限，但我们的样本有效地检测到两组之间具有高统计效力的显著差异。这些发现突出了与小脑中风后记忆损伤相关的潜在社会教育和认知因素。
