Department of Brain and Cognition, University of Amsterdam, Amsterdam, the Netherlands.
Neurology. 2013 Jul 23;81(4):346-52. doi: 10.1212/WNL.0b013e31829c5c86. Epub 2013 Jun 21.
We examined the development of Parkinson disease (PD)-mild cognitive impairment (MCI) in patients with newly diagnosed PD over 5 years using recently proposed consensus criteria, and we assessed the reliability of the criteria.
Patients with PD (n = 123) underwent extensive neuropsychological testing at baseline and after 3 (n = 93) and 5 years (n = 59). Two neuropsychologists independently applied the PD-MCI criteria to examine the interrater and intrarater reliability.
At baseline, 35% of patients had PD-MCI. Three years later, 53% of the patients had PD-MCI. At 5-year follow-up, 20 patients who had PD-MCI at an earlier assessment had converted to PD dementia and 50% of the remaining patients without dementia had MCI. The interrater reliability (kappa) was 0.91. The intrarater reliabilities were 0.85 and 0.96.
Approximately one-third of patients with newly diagnosed PD fulfill the consensus criteria for PD-MCI; after 5 years, this proportion is approximately 50% of patients without dementia. The criteria have good interrater and intrarater reliability.
我们使用最近提出的共识标准，检查了在 5 年内新诊断为帕金森病 (PD)的患者中 PD-轻度认知障碍 (MCI)的发展情况，并评估了这些标准的可靠性。
123 例 PD 患者在基线时以及 3 年(n=93)和 5 年(n=59)时进行了广泛的神经心理学测试。两名神经心理学家独立应用 PD-MCI 标准来检查评分者间和评分者内的可靠性。
基线时，35%的患者患有 PD-MCI。3 年后，53%的患者患有 PD-MCI。在 5 年的随访中，20 名在早期评估中患有 PD-MCI 的患者已转化为 PD 痴呆，而其余无痴呆的患者中有 50%患有 MCI。评分者间的可靠性(kappa)为 0.91。评分者内的可靠性分别为 0.85 和 0.96。
大约三分之一的新诊断为 PD 的患者符合 PD-MCI 的共识标准；5 年后，这一比例约为无痴呆患者的 50%。这些标准具有良好的评分者间和评分者内可靠性。
