在28个国家的样本中，母乳中的DHA含量可预测认知能力。
Maternal milk DHA content predicts cognitive performance in a sample of 28 nations.
作者信息
Lassek William Day, Gaulin Steven J C
机构信息
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Department of Anthropology, University of California, Santa Barbara, California, USA.
出版信息
Matern Child Nutr. 2015 Oct;11(4):773-9. doi: 10.1111/mcn.12060. Epub 2013 Jun 25.
Abstract
Convergent evidence from neuronal biology and hominin brain hypertrophy suggests that omega-3 fatty acids are a limiting resource for neural and cognitive development in Homo sapiens, and therefore that children from populations with higher omega-3 availability should display superior cognitive performance. Using multiple regression, we tested this prediction in a sample of 28 countries, with Programme for International Student Assessment (PISA) math scores in 2009 as an index of cognitive performance, and country-specific breast milk levels of omega-3 docosahexaenoic acid (DHA) as an index of omega-3 availability. Breast milk DHA makes a highly significant contribution to math scores (β = 0.462, P = 0.006), greater in magnitude than the control variables of per capita Gross Domestic Product (PCGDP) and educational expenditures per pupil. Together, dietary fish (positively) and total fat (negatively) explain 61% of the variance in maternal milk DHA in a larger sample of 39 countries.
摘要
来自神经生物学和古人类脑容量增大的趋同证据表明，ω-3脂肪酸是现代人类神经和认知发育的一种限制性资源，因此，来自ω-3可利用性较高人群的儿童应表现出更优的认知能力。我们采用多元回归分析，在28个国家的样本中检验了这一预测，以2009年国际学生评估项目（PISA）数学成绩作为认知能力指标，以各国母乳中ω-3二十二碳六烯酸（DHA）水平作为ω-3可利用性指标。母乳中的DHA对数学成绩有极显著贡献（β = 0.462，P = 0.006），其影响程度大于人均国内生产总值（PCGDP）和人均教育支出等控制变量。在39个国家的更大样本中，膳食鱼类（正向）和总脂肪（负向）共同解释了母乳中DHA含量61%的变异。
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2
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Prostaglandins Leukot Essent Fatty Acids. 2012 Jun;86(6):211-20. doi: 10.1016/j.plefa.2012.04.008. Epub 2012 May 10.
3
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Nutrients. 2011 May;3(5):529-54. doi: 10.3390/nu3050529. Epub 2011 May 10.
4
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Front Evol Neurosci. 2011 Nov 2;3:5. doi: 10.3389/fnevo.2011.00005. eCollection 2011.
5
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Meat Sci. 2004 Jan;66(1):21-32. doi: 10.1016/S0309-1740(03)00022-6.
6
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Nutr Rev. 2011 Mar;69(3):132-44. doi: 10.1111/j.1753-4887.2011.00374.x. Epub 2011 Feb 14.
7
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8
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9
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Am J Clin Nutr. 2010 Jan;91(1):23-31. doi: 10.3945/ajcn.2009.28206. Epub 2009 Nov 18.
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