Lavö B, Knutson L, Lööf L, Hällgren R
Department of Internal Medicine, University Hospital, Uppsala, Sweden.
Gastroenterology. 1990 Sep;99(3):703-7. doi: 10.1016/0016-5085(90)90958-4.
Jejunal prostaglandin E2 secretion in patients with adult celiac disease was studied under basal conditions and after local gliadin challenge. A newly developed tube system with occluding balloons was used to perfuse a jejunal segment. After an initial basal perfusion period of 40 minutes, an average of 12 mg +/- 3 (SEM) of crude gliadin was administered into the perfused segment. Perfusion continued for an additional 100 minutes and prostaglandin E2 was determined in the effluent with a radiometric method. Patients with histologically active celiac disease (n = 7) had higher basal jejunal secretion of prostaglandin E2, 523 +/- 229 pg.cm-1.h-1 (mean +/- SEM), than both celiac patients with normalized small bowel mucosa (n = 6), 160 +/- 44 pg.cm-1.h-1, and healthy controls (n = 18), 184 +/- 38 pg.cm-1.h-1, (P less than 0.05). After gliadin challenge of the jejunal segment, a significant increase (P less than 0.05) in prostaglandin E2 secretion was noted in patients with celiac disease (n = 10). The individual maximum increase was on average fivefold and occurred 60-100 minutes after gliadin administration. In healthy controls (n = 5), no alteration in prostaglandin E2 secretion was detected after gliadin challenge. Enhanced jejunal prostaglandin 2 synthesis may be involved in the pathophysiological processes initiated by gliadin in patients with celiac disease.
在基础条件下以及局部给予麦醇溶蛋白刺激后，对成年乳糜泻患者空肠前列腺素E2的分泌情况进行了研究。使用一种新开发的带有阻塞球囊的导管系统对一段空肠进行灌注。在最初40分钟的基础灌注期后，将平均12毫克±3（标准误）的粗制麦醇溶蛋白注入灌注段。灌注再持续100分钟，并用放射测量法测定流出液中的前列腺素E2。组织学上有活动期乳糜泻的患者（n = 7）空肠前列腺素E2的基础分泌量较高，为523±229皮克·厘米⁻¹·小时⁻¹（平均值±标准误），高于小肠黏膜已恢复正常的乳糜泻患者（n = 6），为160±44皮克·厘米⁻¹·小时⁻¹，以及健康对照者（n = 18），为184±38皮克·厘米⁻¹·小时⁻¹（P < 0.05）。在对空肠段给予麦醇溶蛋白刺激后，乳糜泻患者（n = 10）的前列腺素E2分泌有显著增加（P < 0.05）。个体最大增幅平均为五倍，在给予麦醇溶蛋白后60 - 100分钟出现。在健康对照者（n = 5）中，给予麦醇溶蛋白刺激后未检测到前列腺素E2分泌有变化。空肠前列腺素E2合成增强可能参与了麦醇溶蛋白在乳糜泻患者中引发的病理生理过程。
