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Genomic responses in mouse models poorly mimic human inflammatory diseases.小鼠模型中的基因组反应与人类炎症性疾病的反应相差很大。
Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3507-12. doi: 10.1073/pnas.1222878110. Epub 2013 Feb 11.
2
The biology of nematode- and IL4Rα-dependent murine macrophage polarization in vivo as defined by RNA-Seq and targeted lipidomics.通过 RNA-Seq 和靶向脂质组学定义体内线虫和 IL4Rα 依赖性鼠巨噬细胞极化的生物学。
Blood. 2012 Dec 13;120(25):e93-e104. doi: 10.1182/blood-2012-07-442640. Epub 2012 Oct 16.
3
An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection.TH2 型反应在限制实验性寄生虫感染期间急性组织损伤中的重要作用。
Nat Med. 2012 Jan 15;18(2):260-6. doi: 10.1038/nm.2628.
4
Innate and adaptive immunity to the nematode Strongyloides stercoralis in a mouse model.固有免疫和适应性免疫对粪类圆线虫在小鼠模型中的作用。
Immunol Res. 2011 Dec;51(2-3):205-14. doi: 10.1007/s12026-011-8258-2.
5
Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. alternatively 激活的巨噬细胞产生儿茶酚胺以维持适应性生热。
Nature. 2011 Nov 20;480(7375):104-8. doi: 10.1038/nature10653.
6
Macrophage-mediated inflammation in metabolic disease.巨噬细胞介导体内炎症与代谢疾病。
Nat Rev Immunol. 2011 Oct 10;11(11):738-49. doi: 10.1038/nri3071.
7
Macrophage activation governs schistosomiasis-induced inflammation and fibrosis.巨噬细胞激活调控血吸虫病引起的炎症和纤维化。
Eur J Immunol. 2011 Sep;41(9):2509-14. doi: 10.1002/eji.201141869.
8
Arginase-1-expressing macrophages are dispensable for resistance to infection with the gastrointestinal helminth Trichuris muris.表达精氨酸酶-1 的巨噬细胞对于抵抗胃肠道寄生虫旋毛虫感染是可有可无的。
Parasite Immunol. 2011 Jul;33(7):411-20. doi: 10.1111/j.1365-3024.2011.01300.x.
9
Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation.局部巨噬细胞增殖，而不是从血液中募集，是 TH2 炎症的特征。
Science. 2011 Jun 10;332(6035):1284-8. doi: 10.1126/science.1204351. Epub 2011 May 12.
10
Major basic protein from eosinophils and myeloperoxidase from neutrophils are required for protective immunity to Strongyloides stercoralis in mice.嗜酸性粒细胞中的主要碱性蛋白和中性粒细胞中的髓过氧化物酶是对粪类圆线虫产生保护性免疫所必需的。
Infect Immun. 2011 Jul;79(7):2770-8. doi: 10.1128/IAI.00931-10. Epub 2011 Apr 11.

人和鼠的巨噬细胞与中性粒细胞协同作用杀死粪类圆线虫的幼虫。

Human and mouse macrophages collaborate with neutrophils to kill larval Strongyloides stercoralis.

机构信息

Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

出版信息

Infect Immun. 2013 Sep;81(9):3346-55. doi: 10.1128/IAI.00625-13. Epub 2013 Jun 24.

DOI:10.1128/IAI.00625-13
PMID:23798541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3754234/
Abstract

Macrophages are multifunctional cells that are active in TH1- and TH2-mediated responses. In this study, we demonstrate that human and mouse macrophages collaborate with neutrophils and complement to kill the parasite Strongyloides stercoralis in vitro. Infection of mice with worms resulted in the induction of alternatively activated macrophages (AAM) within the peritoneal cavity. These cells killed the worms in vivo and collaborated with neutrophils and complement during the in vitro killing process. AAM generated in vitro killed larvae more rapidly than naive macrophages, which killed larvae after a longer time period. In contrast, classically activated macrophages were unable to kill larvae either in vitro or in vivo. This study adds macrophages to the armamentarium of immune components that function in elimination of parasitic helminths and demonstrate a novel function by which AAM control large extracellular parasites.

摘要

巨噬细胞是多功能细胞，在 TH1 和 TH2 介导的反应中活跃。在这项研究中，我们证明人类和鼠类巨噬细胞与中性粒细胞和补体合作，在体外杀死寄生虫旋毛虫。用蠕虫感染小鼠导致腹腔内诱导出替代性激活的巨噬细胞（AAM）。这些细胞在体内杀死蠕虫，并在体外杀伤过程中与中性粒细胞和补体合作。体外生成的 AAM 比幼稚巨噬细胞更快地杀死幼虫，幼稚巨噬细胞在较长时间后才杀死幼虫。相比之下，经典激活的巨噬细胞在体外或体内均无法杀死幼虫。这项研究将巨噬细胞添加到免疫成分的武器库中，这些免疫成分在消除寄生虫蠕虫方面发挥作用，并展示了 AAM 控制大型细胞外寄生虫的新功能。