Department of Neurology and Neurosurgery, UNIFESP, Rua Botucatu 740, São Paulo, SP, Brazil, 04023-900.
Curr Pain Headache Rep. 2013 Aug;17(8):355. doi: 10.1007/s11916-013-0355-6.
Recent studies showed that most cells have receptors and enzymes responsible for metabolism of vitamin D. Several diseases have been linked to vitamin D deficiency, such as hypertension, diabetes, depression, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and chronic pain syndromes such as fibromyalgia. The association between fibromyalgia and vitamin D deficiency is very controversial in the literature with conflicting studies and methodological problems, which leads to more questions than answers. The purpose of this article is to raise questions about the association of hypovitaminosis D with fibromyalgia considering causal relationships, treatment, and pathophysiological explanations.
最近的研究表明，大多数细胞都有负责维生素 D 代谢的受体和酶。一些疾病与维生素 D 缺乏有关，如高血压、糖尿病、抑郁症、阿尔茨海默病、帕金森病、多发性硬化症和慢性疼痛综合征，如纤维肌痛。纤维肌痛与维生素 D 缺乏之间的关联在文献中存在很大争议，研究结果相互矛盾，存在方法学问题，这导致提出的问题多于答案。本文的目的是提出关于维生素 D 缺乏与纤维肌痛之间关联的问题，考虑因果关系、治疗和病理生理解释。
