Akar Nezihe, Sayıner Çaglar Nil, Aytekin Ebru, Akar Abdullah, Aksu Özge, Öz Nuran
Department of Physical Medicine and Rehabilitation, Health Sciences University, Istanbul Training and Research Hospital, Istanbul, Turkey.
Turk J Phys Med Rehabil. 2020 Mar 3;66(1):67-72. doi: 10.5606/tftrd.2020.2928. eCollection 2020 Mar.
This study aims to investigate the prevalence of fibromyalgia syndrome (FMS) among patients with low and adequate vitamin D levels in premenopausal women.
Between October 2012 and April 2013, a total of 80 premenopausal patients (mean age 38.1±7.1 years; range, 18 to 50 years) with non-specific musculoskeletal symptoms were included in the study. The determination of 25-hydroxyvitamin D3 (25(OH)D3) deficiency was based on a reference value of 25 ng/mL. Patients with deficient serum 25(OH)D3 levels (<25 ng/mL, n=40) comprised the patient group, while those with adequate serum 25(OH)D3 levels (≥25 ng/mL, n=40) comprised the control group. Data including demographic characteristics, laboratory parameters (i.e., calcium, phosphorus, alkaline phosphatase [ALP], and parathyroid hormone [PTH]), and clinical findings (i.e., proximal muscle weakness [PMW] and periarticular sensitivity [PAS]) were recorded and compared between the groups. Pain severity was evaluated using the visual analog scale (VAS), psychological status was evaluated using the Beck Depression Inventory (BDI), and quality of life (QoL) was evaluated using the Short Form 36 (SF-36). The diagnosis of FMS was made based on the 2010 criteria of the American College of Rheumatology.
Although there were no statistically significant differences in the demographic characteristics between the groups, ALP and PTH levels were higher in the patient group (p<0.05). The VAS, frequency of FMS, PMW, and PAS were also significantly higher in the patient group (p<0.05). Depression and the mental and physical component scores of the SF-36 did not significantly differ between the two groups (p<0.05).
Our study results suggest that patients with low 25(OH)D3 levels may more frequently experience FMS and pain than healthy individuals.
本研究旨在调查绝经前女性维生素D水平低和充足的患者中纤维肌痛综合征（FMS）的患病率。
2012年10月至2013年4月期间，共有80名有非特异性肌肉骨骼症状的绝经前患者（平均年龄38.1±7.1岁；范围18至50岁）纳入本研究。25-羟基维生素D3（25(OH)D3）缺乏的判定基于25 ng/mL的参考值。血清25(OH)D3水平不足（<25 ng/mL，n = 40）的患者组成患者组，而血清25(OH)D3水平充足（≥25 ng/mL，n = 40）的患者组成对照组。记录并比较两组间包括人口统计学特征、实验室参数（即钙、磷、碱性磷酸酶[ALP]和甲状旁腺激素[PTH]）以及临床发现（即近端肌无力[PMW]和关节周围敏感性[PAS]）的数据。使用视觉模拟量表（VAS）评估疼痛严重程度，使用贝克抑郁量表（BDI）评估心理状态，使用简短健康调查问卷（SF-36）评估生活质量（QoL）。FMS的诊断基于美国风湿病学会2010年标准。
尽管两组间人口统计学特征无统计学显著差异，但患者组的ALP和PTH水平较高（p<0.05）。患者组的VAS、FMS频率、PMW和PAS也显著更高（p<0.05）。两组间抑郁以及SF-36的心理和身体成分得分无显著差异（p<0.05）。
我们的研究结果表明，25(OH)D3水平低的患者可能比健康个体更频繁地经历FMS和疼痛。
