The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 101-20, Pasadena, California 91125, USA.
Org Lett. 2013 Jul 5;15(13):3480-3. doi: 10.1021/ol401514s. Epub 2013 Jun 26.
A catalytic enantioselective double allylic alkylation reaction has been employed in the synthesis of the core of the gagunin diterpenoids. Enantioenriched material was advanced in 11 steps to afford the core of the highly oxygenated target, which includes two all-carbon quaternary stereocenters.
一种催化对映选择性双烯丙基烷基化反应已被用于 gagunin 二萜类化合物核心的合成。通过 11 步反应，得到了具有丰富手性的产物，进一步合成了高度氧化的目标化合物核心，其中包括两个全碳季碳中心。
