Department of Pathology, The Ohio State University, Columbus, OH, USA.
Exp Dermatol. 2013 Aug;22(8):507-10. doi: 10.1111/exd.12169. Epub 2013 Jun 27.
Mast cells (MCs) are an important part of the innate immune system and are abundant in barrier organs such as the skin. They are known primarily for initiating allergic reactions, but many other biological functions have now been described for these cells. Studies have indicated that during wound repair, MCs enhance acute inflammation, stimulate reepithelialization and angiogenesis, and promote scarring. MCs have also been linked to abnormal healing, with high numbers of MCs observed in chronic wounds, hypertrophic scars and keloids. Although MCs have gained attention in the wound healing field, several unique features of MCs have yet to be examined in the context of cutaneous repair. These include the ability of MCs to: (i) produce anti-inflammatory mediators; (ii) release mediators without degranulating; and (iii) change their phenotype. Recent findings highlight the complexity of MCs and suggest that more information is needed to understand their complete range of activities during repair.
肥大细胞（MCs）是先天免疫系统的重要组成部分，在皮肤等屏障器官中丰富存在。它们主要以引发过敏反应而闻名，但现在已经描述了这些细胞的许多其他生物学功能。研究表明，在伤口修复过程中，MC 增强急性炎症、刺激再上皮化和血管生成，并促进瘢痕形成。MC 也与异常愈合有关，在慢性伤口、肥厚性瘢痕和瘢痕疙瘩中观察到大量的 MC。尽管 MC 在伤口愈合领域受到关注，但在皮肤修复方面，MC 的一些独特特征尚未得到研究。这些特征包括 MC 产生抗炎介质的能力：（i）释放不脱颗粒的介质；和（iii）改变其表型。最近的发现强调了 MC 的复杂性，并表明需要更多的信息来了解它们在修复过程中的完整活动范围。
