Qu Hong-Hong, Cui Li-Hong, Wang Ke, Wang Peng, Song Chun-Hua, Wang Kai-Juan, Zhang Jian-Ying, Dai Li-Ping
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China E-mail :
Asian Pac J Cancer Prev. 2013;14(5):3163-8. doi: 10.7314/apjcp.2013.14.5.3163.
Methylenetetrahydrofolate reductase (MTHFR) plays a central role in folate metabolism. This study with 381 esophageal cancer patients and 432 healthy controls was conducted to examine the association of MTHFR C677T and A1298C polymorphisms with susceptibility to esophageal cancer (EC) in a Chinese population. Compared with the CC genotype of MTHFR C677T, subjects carrying homozygote TT and variant genotypes (CT+TT) demonstrated reduced risk of EC with adjusted ORs (95% CI) of 0.44 (0.28-0.71) and 0.57 (0.37-0.88), respectively. However, no association was found between the MTHFR A1298C polymorphism and the risk of EC. Comparing to haplotype CA, haplotypes TA and TC could reduce the susceptibility to EC with adjusted ORs (95% CI) of 0.61(0.47-0.79) and 0.06 (0.01-0.43), respectively. In conclusion, the present study suggested that the MTHFR C677T polymorphism can markedly influence the risk of EC in Chinese.
亚甲基四氢叶酸还原酶（MTHFR）在叶酸代谢中起核心作用。本研究纳入了381例食管癌患者和432例健康对照，旨在探讨中国人群中亚甲基四氢叶酸还原酶C677T和A1298C基因多态性与食管癌（EC）易感性的关系。与MTHFR C677T的CC基因型相比，携带纯合子TT和变异基因型（CT + TT）的受试者发生食管癌的风险降低，校正后的比值比（95%可信区间）分别为0.44（0.28 - 0.71）和0.57（0.37 - 0.88）。然而，未发现MTHFR A1298C基因多态性与食管癌风险之间存在关联。与单倍型CA相比，单倍型TA和TC可降低食管癌易感性，校正后的比值比（95%可信区间）分别为0.61（0.47 - 0.79）和0.06（0.01 - 0.43）。总之，本研究表明MTHFR C677T基因多态性可显著影响中国人患食管癌的风险。
