Department of Microbiology, Harbin Medical University, Harbin, 150081, China; Heilongjiang key Laboratory of Infection and Immunity, Heilongjiang Province, China; Pathogenic-Biological key laboratory, Heilongjiang Higher Education Institutions, 150081, Harbin, China.
Obesity (Silver Spring). 2014 Mar;22(3):895-900. doi: 10.1002/oby.20533. Epub 2013 Dec 2.
Serological studies on the relationship between adenovirus 36 (Ad36) and an increased risk of obesity development have shown conflicting results. We reviewed the published studies and carried out a meta-analysis to explore this relationship.
PubMed was searched until December 2012 for the relative references with sufficient information to estimate odds ratios (ORs) and 95% confidence intervals (CIs). A total of 11 case-control studies, including 2508 obese subjects and 3005 controls, were selected.
Compared with nonobese controls, Ad36 infection significantly increased the obesity risk by a pooled OR of 1.60 (95% CI = 1.14-2.25; P < 0.01). Meta-regression showed that the types of subject and obesity assessments were potential risk factors. In the subgroup analysis, a significantly increased risk was found in children (OR = 1.95; 95% CI = 1.34-2.85; z = 3.45; P < 0.01) and those with an obesity assessment of BMI ≥ 30 kg/cm2 (OR = 1.89; 95% CI = 1.15-3.10; P < 0.05).
Ad36 infection is associated with an increased risk of obesity development. To our knowledge, this is the first report to reveal the significant relationship in children with a serological data analysis.
关于腺病毒 36（Ad36）与肥胖发展风险增加之间关系的血清学研究结果存在矛盾。我们对已发表的研究进行了综述，并开展了荟萃分析以探索这种关系。
检索了 PubMed 数据库截至 2012 年 12 月的相关参考文献，以获取有足够信息来评估比值比（OR）和 95%置信区间（CI）的研究。共纳入了 11 项病例对照研究，包括 2508 例肥胖患者和 3005 例对照。
与非肥胖对照相比，Ad36 感染使肥胖的风险显著增加，合并 OR 为 1.60（95%CI=1.14-2.25；P<0.01）。Meta 回归显示，研究对象的类型和肥胖评估方法是潜在的危险因素。在亚组分析中，发现儿童（OR=1.95；95%CI=1.34-2.85；z=3.45；P<0.01）和肥胖评估为 BMI≥30 kg/cm2 的人群（OR=1.89；95%CI=1.15-3.10；P<0.05）中风险显著增加。
Ad36 感染与肥胖发展风险增加相关。据我们所知，这是第一项基于血清学数据分析揭示儿童中存在显著相关性的报告。
