Departments of Medicine and Obstetrics & Gynecology, University of Michigan, Ann Arbor, Michigan, USA.
Obesity (Silver Spring). 2014 Mar;22(3):882-7. doi: 10.1002/oby.20527. Epub 2013 Aug 23.
To examine whether estrogen use potentiates weight loss interventions via sex steroid levels and whether endogenous sex steroid levels predict response to weight loss interventions among women not using estrogen.
The Diabetes Prevention Program randomized overweight or obese dysglycemic participants to lifestyle change with the goals of weight reduction of >7% of initial weight and 150 minutes per week of exercise, metformin, or placebo. In this secondary analysis, we examined sex steroid levels and reductions in weight and waist circumference (WC) among postmenopausal women using (n = 324) and not using (n = 382) oral estrogen.
Estrogen users and nonusers randomized to lifestyle change and metformin both lost significant amounts of weight compared to placebo. Reductions in weight and WC over 1 year associated with randomization arm were not associated with baseline sex steroid levels among estrogen users or nonusers.
Among estrogen users, baseline sex steroids were not associated with reductions in weight or WC, suggesting that exogenous estrogen does not potentiate weight loss by altering sex steroids. Among nonestrogen users, baseline sex steroids were not associated with reductions in weight or WC.
研究雌激素的使用是否通过性激素水平增强减肥干预的效果，以及内源性性激素水平是否可以预测不使用雌激素的女性对减肥干预的反应。
糖尿病预防计划将超重或肥胖的血糖异常参与者随机分为生活方式改变组，目标是减轻初始体重的>7%，每周进行 150 分钟的运动、二甲双胍或安慰剂。在这项二次分析中，我们研究了使用（n=324）和不使用（n=382）口服雌激素的绝经后妇女的性激素水平以及体重和腰围（WC）的减少情况。
随机分配到生活方式改变和二甲双胍组的雌激素使用者和非使用者与安慰剂相比均显著减轻体重。与随机分组臂相关的 1 年内体重和 WC 的减少与雌激素使用者或非使用者的基线性激素水平无关。
在雌激素使用者中，基线性激素与体重或 WC 的减少无关，表明外源性雌激素不会通过改变性激素来增强减肥效果。在非雌激素使用者中，基线性激素与体重或 WC 的减少无关。
