Laboratoire de Pharmacocinétique et de Toxicologie Cliniques, Groupe Hospitalier du Havre, BP 24, 76083 Le Havre, France.
Bull Environ Contam Toxicol. 2013 Aug;91(2):171-6. doi: 10.1007/s00128-013-1030-7. Epub 2013 Jun 27.
A rapid, sensitive and highly specific HPLC-MS/MS method with direct on-line preparation was applied for the determination of 20 common pharmaceuticals in hospital and urban wastewater. Median drug concentrations were quite similar in the majority of samples, cerca 1 μg L⁻¹ ranging from 0.06 to 2.67 μg L⁻¹ in both water. Pharmaceutical hospital contribution, below 1 %, was negligible, as compared to the huge amount in the municipal plant flow. Due to only partial elimination in the plant, hundreds of kilograms of harmful waste per year are discharged in the River Seine. Therefore, to reduce potential human and environmental exposure, a topic of major concern, an efficient drug treatment procedure should be used at the municipal plant stage in order to reduce urban wastewater pollution. The HPLC-MS/MS method could be a very useful tool to optimize the pharmaceutical wastewater treatment process.
建立了一种快速、灵敏、专属性强的 HPLC-MS/MS 直接在线净化法，用于测定医院污水和城市污水中 20 种常见药物。大部分样品中药物浓度中位数非常相似，水相中浓度范围在 0.06 至 2.67μg/L 之间，中位数为 1μg/L。与城市污水处理厂的污水流量相比，医院污水的贡献较小（<1%）。由于在处理厂中仅部分去除，每年有数百公斤有害废物排入塞纳河。因此，为了减少潜在的人体和环境暴露，这是一个主要关注的问题，应该在城市污水处理厂阶段使用有效的药物处理程序，以减少城市污水的污染。HPLC-MS/MS 方法可以作为优化药物废水处理过程的非常有用的工具。
