State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, 210046, Jiangsu, People's Republic of China.
Environ Sci Pollut Res Int. 2014 Jun;21(12):7276-84. doi: 10.1007/s11356-014-2613-5. Epub 2014 Feb 26.
To understand the transport and fate of antibiotic resistance genes in wastewater treatment plants, 12 resistance genes (ten tetracycline resistance genes, two sulfonamides genes) and class 1 integron gene (intI1) were studied in five wastewater treatment plants with different treatment processes and different sewage sources. Among these resistance genes, sulfonamides genes (sul1 and sul2) were of the most prevalent genes with detection frequency of 100%. The effluent water contained fewer types of resistance genes than the influent in most selected plants. The abundance of five quantified resistance genes (tetG, tetW, tetX, sul1, and intI1) decreased in effluent of plants treating domestic or industrial wastewater with anaerobic/aerobic or membrane bioreactor (MBR) technologies, but tetG, tetX, sul1, and intI1 increased along the treatment units of plants treating vitamin C production wastewater by anaerobic/aerobic technology. In plant treating cephalosporins production wastewater by UASB/aerobic process, the quantities of tetG, tetX, and sul1 first decreased in anaerobic effluent water but then increased in aerobic effluent water.
为了了解抗生素耐药基因在污水处理厂中的迁移和归宿，选择了具有不同处理工艺和污水来源的 5 个污水处理厂，研究了 12 种耐药基因（10 种四环素耐药基因、2 种磺胺类基因）和 1 类整合子基因（intI1）。在所研究的耐药基因中，磺胺类基因（sul1 和 sul2）是最普遍的基因，检出率为 100%。与大多数选定的工厂相比，出水中的耐药基因种类较少。在处理生活污水或工业污水的厌氧/好氧或膜生物反应器（MBR）工艺的污水处理厂中，五种定量耐药基因（tetG、tetW、tetX、sul1 和 intI1）的丰度在出水中降低，但在处理维生素 C 生产废水的厌氧/好氧工艺的处理单元中，tetG、tetX、sul1 和 intI1 增加。在 UASB/好氧工艺处理头孢菌素生产废水的工厂中，tetG、tetX 和 sul1 的数量先在厌氧出水时减少，但随后在好氧出水中增加。
