Uenoyama K, Tamura M, Kinoshita C, Kanagawa R, Ohmi S, Nakao T, Saika S
Department of Ophthalmology, Wakayama Medical College, Japan.
J Cataract Refract Surg. 1990 Jul;16(4):465-70. doi: 10.1016/s0886-3350(13)80800-0.
The major cellular components on intraocular lenses experimentally implanted in the rabbit eye and in the mouse peritoneal space were examined. They consisted of macrophages and their metamorphosed epithelioid cells with occasional formations of foreign-body giant cells from the fusion of the macrophage-related cells. Lymphocytes, individually and in clusters, were also seen on the lenses implanted in the mouse peritoneal space but rarely on those implanted in the rabbit eye. Macrophages, epithelioid cells, and giant cells exhibited active phagocytosis on the implanted intraocular lenses. These cells phagocytized not only minor foreign particles such as artificially fed latex or carbon colloids but also living cells including erythrocytes, leukocytes, and lymphocytes. The nuclear pattern of the giant cell formation process initially assumed a centrally located nuclear distribution of a foreign-body giant cell type, and then a peripherally located Langhans type distribution when the number of nuclei reached about five in both the mouse peritoneal space and the rabbit eye chamber. Ultra-large giant cells containing a number of nuclei, however, were only observed on lenses implanted in the rabbit eye, demonstrating a difference between the two environments.
对实验性植入兔眼和小鼠腹腔的人工晶状体上的主要细胞成分进行了检查。它们由巨噬细胞及其变形的上皮样细胞组成，偶尔会有巨噬细胞相关细胞融合形成异物巨细胞。在植入小鼠腹腔的人工晶状体上也可见单个或成群的淋巴细胞，但在植入兔眼的人工晶状体上则很少见。巨噬细胞、上皮样细胞和巨细胞对植入的人工晶状体表现出活跃的吞噬作用。这些细胞不仅吞噬如人工喂食的乳胶或碳胶体等微小异物颗粒，还吞噬包括红细胞、白细胞和淋巴细胞在内的活细胞。巨细胞形成过程的核模式最初呈现异物巨细胞类型的核集中分布，当核数量在小鼠腹腔和兔眼房达到约五个时，随后呈现周边分布的朗汉斯型。然而，仅在植入兔眼的人工晶状体上观察到含有多个核的超大巨细胞，这表明两种环境之间存在差异。
