Uenoyama K, Kanagawa R, Tamura M, Matoba M, Enomoto Y, Ohmi S
Department of Ophthalmology, Wakayama Medical College, Japan.
J Cataract Refract Surg. 1988 Mar;14(2):187-91. doi: 10.1016/s0886-3350(88)80094-4.
Polymethylmethacrylate and silicone intraocular lenses (IOLs) were implanted in the rabbit eye and in the mouse peritoneal space to study cellular response to the implanted IOL. Animals were sacrificed at various times after implantation. The removed IOLs were properly fixed and stained using Wolter's implant cytology technique. Scanning and transmission electron microscopic studies were performed. Macrophages, lymphocytes, and fibroblast-like cells were the major components identified. Occasional formations of foreign-body giant cells were seen. The responses observed on IOLs implanted in the rabbit eye were generally milder than those observed on IOLs implanted in the mouse peritoneal space.
将聚甲基丙烯酸甲酯和硅胶人工晶状体（IOL）植入兔眼和小鼠腹腔，以研究细胞对植入的人工晶状体的反应。植入后在不同时间处死动物。取出的人工晶状体采用沃尔特植入细胞学技术进行妥善固定和染色。进行扫描和透射电子显微镜研究。巨噬细胞、淋巴细胞和成纤维样细胞是鉴定出的主要成分。偶尔可见异物巨细胞形成。植入兔眼中的人工晶状体观察到的反应通常比植入小鼠腹腔中的人工晶状体观察到的反应更轻微。
