Department of Biology, Concordia University, Montreal, QC, Canada.
IUBMB Life. 2013 Aug;65(8):665-74. doi: 10.1002/iub.1183. Epub 2013 Jul 2.
Organelles within a eukaryotic cell respond to age-related intracellular stresses and environmental factors by altering their functional states to generate, direct and process the flow of interorganellar information that is essential for establishing a pro- or antiaging cellular pattern. The scope of this review is to critically analyze recent progress in understanding how various intercompartmental (i.e., organelle-organelle and organelle-cytosol) communications regulate cellular aging in evolutionarily distant eukaryotes. Our analysis suggests a model for an intricate network of intercompartmental communications that underly cellular aging in eukaryotic organisms across phyla. This proposed model posits that the numerous directed, coordinated and regulated organelle-organelle and organelle-cytosol communications integrated into this network define the long-term viability of a eukaryotic cell and, thus, are critical for regulating cellular aging.
真核细胞内的细胞器通过改变其功能状态来应对与年龄相关的细胞内应激和环境因素，从而产生、指导和处理细胞器间信息的流动，这些信息对于建立促进或抑制细胞衰老的模式至关重要。本综述的范围是批判性地分析最近在理解如何通过各种细胞间（即细胞器-细胞器和细胞器-细胞质）通讯来调节进化上不同的真核生物的细胞衰老方面的进展。我们的分析提出了一个在整个门的真核生物中细胞衰老的细胞间通讯的复杂网络模型。该模型假设，这个网络中整合的众多定向的、协调的和受调控的细胞器-细胞器和细胞器-细胞质通讯定义了真核细胞的长期生存能力，因此对于调节细胞衰老至关重要。
