Otsuka Rei, Kato Yuki, Imai Tomoko, Ando Fujiko, Shimokata Hiroshi
Department for Development of Preventive Medicine, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Lipids. 2013 Jul;48(7):719-27. doi: 10.1007/s11745-013-3763-9. Epub 2013 Feb 7.
Docosahexaenoic acid (DHA) and arachidonic acid (ARA) are the predominant long-chain polyunsaturated fatty acids (PUFA) among membrane phospholipids in the mammalian brain and neural tissues. This cross-sectional study examined age effects on serum eicosapentaenoic acid (EPA), DHA, and ARA compositions assessed with reference to dietary intakes among 1,014 Japanese men and 1,028 Japanese women aged 40-79 years. Venous blood was collected early in the morning after at least 12-h fasting. Serum fatty acid (FA) compositions were expressed as molar percentages of the total FA (mol% of total). Diet was assessed using a 3-day dietary record that included photographs. Participants were categorized into groups by sex and age (40-49, 50-59, 60-69, and 70-79 years). Intakes of fish, EPA, and DHA tended to increase with age. Significant positive correlations between serum FA composition and the corresponding weight percentage of total FA intake were observed for EPA and DHA in all sex and age groups, and for ARA among females in their 40s. Serum EPA and DHA compositions were higher, while ARA decreased with age, and these associations remained consistent even after adjusting for corresponding FA intake. These results suggest potential effects of age on differences in blood EPA, DHA, and ARA compositions, independent of corresponding FA intake among community-dwelling Japanese men and women.
二十二碳六烯酸（DHA）和花生四烯酸（ARA）是哺乳动物大脑和神经组织中膜磷脂里主要的长链多不饱和脂肪酸（PUFA）。这项横断面研究调查了年龄对血清二十碳五烯酸（EPA）、DHA和ARA组成的影响，研究对象为1014名40至79岁的日本男性和1028名40至79岁的日本女性，并参照了他们的饮食摄入量。在至少禁食12小时后的清晨采集静脉血。血清脂肪酸（FA）组成以总脂肪酸的摩尔百分比表示（占总脂肪酸的摩尔%）。饮食通过一份包括照片的3天饮食记录进行评估。参与者按性别和年龄（40 - 49岁、50 - 59岁、60 - 69岁和70 - 79岁）分组。鱼类、EPA和DHA的摄入量往往随年龄增长而增加。在所有性别和年龄组中，EPA和DHA的血清FA组成与相应总FA摄入量的重量百分比之间存在显著正相关，在40多岁的女性中，ARA也存在这种相关性。血清EPA和DHA组成较高，而ARA随年龄下降，即使在调整相应FA摄入量后，这些关联仍然一致。这些结果表明，年龄对日本社区居住的男性和女性血液中EPA、DHA和ARA组成的差异可能有潜在影响，且独立于相应的FA摄入量。
