Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.
Environ Health Perspect. 2013 Sep;121(9):1061-7. doi: 10.1289/ehp.1104845. Epub 2013 Jul 2.
Evidence suggests that air pollution is associated with atherosclerosis and that traffic-related particles are a particularly important contributor to the association.
We investigated the association between long-term exposure to black carbon, a correlate of traffic particles, and intima-media thickness of the common carotid artery (CIMT) in elderly men residing in the greater Boston, Massachusetts, area.
We estimated 1-year average exposures to black carbon at the home addresses of Normative Aging Study participants before their first CIMT measurement. The association between estimated black carbon levels and CIMT was estimated using mixed effects models to account for repeated outcome measures. In secondary analyses, we examined whether living close to a major road or average daily traffic within 100 m of residence was associated with CIMT.
There were 380 participants (97% self-reported white race) with an initial visit between 2004 and 2008. Two or three follow-up CIMT measurements 1.5 years apart were available for 340 (89%) and 260 (68%) men, respectively. At first examination, the average ± SD age was 76 ± 6.4 years and the mean ± SD CIMT was 0.99 ± 0.18 mm. A one-interquartile range increase in 1-year average black carbon (0.26 µg/m3) was associated with a 1.1% higher CIMT (95% CI: 0.4, 1.7%) based on a fully adjusted model.
Annual mean black carbon concentration based on spatially resolved exposure estimates was associated with CIMT in a population of elderly men. These findings support an association between long-term air pollution exposure and atherosclerosis.
有证据表明，空气污染与动脉粥样硬化有关，而与交通相关的颗粒是导致这种关联的一个特别重要的因素。
我们研究了长期暴露于黑碳（交通颗粒的一种相关物）与居住在马萨诸塞州大波士顿地区的老年男性的颈总动脉内膜-中层厚度（CIMT）之间的关系。
我们在 Normative Aging Study 参与者首次 CIMT 测量之前，估计了他们家庭住址处 1 年平均黑碳暴露量。使用混合效应模型来估计估计的黑碳水平与 CIMT 之间的关联，以考虑到重复的结果测量。在二次分析中，我们研究了居住在距离主要道路或居住地 100 米范围内的平均日交通量较近是否与 CIMT 相关。
共有 380 名参与者（97%自报为白人种族）在 2004 年至 2008 年期间进行了首次就诊。340 名（89%）和 260 名（68%）男性分别有两次或三次间隔 1.5 年的后续 CIMT 测量。在首次检查时，平均年龄为 76 ± 6.4 岁，平均 CIMT 为 0.99 ± 0.18mm。基于完全调整的模型，1 年平均黑碳（0.26μg/m3）增加一个四分位间距与 CIMT 增加 1.1%（95%CI：0.4，1.7%）相关。
基于空间分辨率暴露估计的年平均黑碳浓度与老年男性人群的 CIMT 相关。这些发现支持长期空气污染暴露与动脉粥样硬化之间的关联。
