Liu Yanli, Singh Anup K
1Sandia National Laboratories, Livermore, CA, USA.
J Lab Autom. 2013 Dec;18(6):446-54. doi: 10.1177/2211068213494389. Epub 2013 Jul 2.
Elucidation of the heterogeneity of cells is a challenging task due to the lack of efficient analytical tools to make measurements with single-cell resolution. Microfluidics has emerged as a powerful platform for single-cell analysis with the ability to manipulate small volume and integrate multiple sample preparation steps into one device. In this review, we discuss the differentiating advantages of microfluidic platforms that have been demonstrated for single-cell protein analysis.
由于缺乏能够以单细胞分辨率进行测量的高效分析工具,阐明细胞的异质性是一项具有挑战性的任务。微流控技术已成为单细胞分析的强大平台,它能够处理小体积样本,并将多个样品制备步骤集成到一个设备中。在本综述中,我们讨论了已被证明用于单细胞蛋白质分析的微流控平台的独特优势。