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用于 CyberKnife® 和配备微叶片准直器和集束筒的线性加速器的若干探测器的小射野输出因子测量和校正因子确定。

Small fields output factors measurements and correction factors determination for several detectors for a CyberKnife® and linear accelerators equipped with microMLC and circular cones.

机构信息

Institut de Radioprotection et de Sûreté Nucléaire (IRSN), BP17, 92262 Fontenay-aux-Roses Cedex, France.

出版信息

Med Phys. 2013 Jul;40(7):071725. doi: 10.1118/1.4811139.

Abstract

PURPOSE

The use of small photon fields is now an established practice in stereotactic radiosurgery and radiotherapy. However, due to a lack of lateral electron equilibrium and high dose gradients, it is difficult to accurately measure the dosimetric quantities required for the commissioning of such systems. Moreover, there is still no metrological dosimetric reference for this kind of beam today. In this context, the first objective of this work was to determine and to compare small fields output factors (OF) measured with different types of active detectors and passive dosimeters for three types of facilities: a CyberKnife(®) system, a dedicated medical linear accelerator (Novalis) equipped with m3 microMLC and circular cones, and an adaptive medical linear accelerator (Clinac 2100) equipped with an additional m3 microMLC. The second one was to determine the kQclin,Qmsr (fclin,fmsr) correction factors introduced in a recently proposed small field dosimetry formalism for different active detectors.

METHODS

Small field sizes were defined either by microMLC down to 6 × 6 mm(2) or by circular cones down to 4 mm in diameter. OF measurements were performed with several commercially available active detectors dedicated to measurements in small fields (high resolution diodes: IBA SFD, Sun Nuclear EDGE, PTW 60016, PTW 60017; ionizing chambers: PTW 31014 PinPoint chamber, PTW 31018 microLion liquid chamber, and PTW 60003 natural diamond). Two types of passive dosimeters were used: LiF microcubes and EBT2 radiochromic films.

RESULTS

Significant differences between the results obtained by several dosimetric systems were observed, particularly for the smallest field size for which the difference in the measured OF reaches more than 20%. For passive dosimeters, an excellent agreement was observed (better than 2%) between EBT2 and LiF microcubes for all OF measurements. Moreover, it has been shown that these passive dosimeters do not require correction factors and can then be used as reference dosimeters. Correction factors for the active detectors have then been determined from the mean experimental OF measured by the passive dosimeters.

CONCLUSIONS

Four sets of correction factors needed to apply the new small field dosimetry formalism are provided for several active detectors. A protocol for small photon beams OF determination based on passive dosimeters measurements has been recently proposed to French radiotherapy treatment centers.

摘要

目的

立体定向放射外科和放射治疗中现已广泛采用小光子束。然而,由于侧向电子平衡缺失和剂量梯度较高,精确测量此类系统的调试所需的剂量学量值较为困难。此外,目前还没有针对这种射束的计量学剂量参考标准。在这种情况下,这项工作的首要目标是,使用三种设备(CyberKnife®系统、配备 m3 微多叶准直器和圆形准直器的专用医用直线加速器 Novalis 以及配备附加 m3 微多叶准直器的自适应医用直线加速器 Clinac 2100),分别用不同类型的有源探测器和无源剂量计来测量和比较小射野输出因子(OF)。其次,为了确定最近提出的小射野剂量学公式中引入的 kQclin,Qmsr(fclin,fmsr)校正因子,我们针对不同的有源探测器进行了测定。

方法

小射野尺寸分别通过微多叶准直器缩小至 6×6mm² 或通过直径缩小至 4mm 的圆形准直器来定义。使用几种市售的专用小射野测量有源探测器(高分辨率二极管:IBA SFD、Sun Nuclear EDGE、PTW 60016、PTW 60017;电离室:PTW 31014 PinPoint 室、PTW 31018 microLion 液体电离室和 PTW 60003 天然金刚石)进行 OF 测量。使用两种类型的无源剂量计:LiF 微球和 EBT2 光致变色胶片。

结果

几个剂量测量系统的结果存在显著差异,尤其是对于最小射野尺寸,其测量的 OF 差异超过 20%。对于无源剂量计,EBT2 和 LiF 微球在所有 OF 测量中均表现出极好的一致性(优于 2%)。此外,结果表明这些无源剂量计无需校正因子,因此可用作参考剂量计。然后,通过无源剂量计测量的平均实验 OF 值确定了有源探测器的校正因子。

结论

为几种有源探测器提供了应用新小射束剂量学公式所需的四组校正因子。最近已向法国放射治疗中心提出了基于无源剂量计测量的小光子束 OF 测定协议。

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