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使用塑料闪烁探测器和其他立体定向剂量计对小射野整体散射因子和剂量分布进行对比研究:以 CyberKnife 为例。

A comparative study of small field total scatter factors and dose profiles using plastic scintillation detectors and other stereotactic dosimeters: the case of the CyberKnife.

机构信息

Département de Physique, Université Laval, Québec, Québec, Canada.

出版信息

Med Phys. 2013 Jan;40(1):011719. doi: 10.1118/1.4772190.

Abstract

PURPOSE

Small-field dosimetry is challenging, and the main limitations of most dosimeters are insufficient spatial resolution, water nonequivalence, and energy dependence. The purpose of this study was to compare plastic scintillation detectors (PSDs) to several commercial stereotactic dosimeters by measuring total scatter factors and dose profiles on a CyberKnife system.

METHODS

Two PSDs were developed, having sensitive volumes of 0.196 and 0.785 mm(3), and compared with other detectors. The spectral discrimination method was applied to subtract Čerenkov light from the signal. Both PSDs were compared to four commercial stereotactic dosimeters by measuring total scatter factors, namely, an IBA dosimetry stereotactic field diode (SFD), a PTW 60008 silicon diode, a PTW 60012 silicon diode, and a microLion. The measured total scatter factors were further compared with those of two independent Monte Carlo studies. For the dose profiles, two commercial detectors were used for the comparison, i.e., a PTW 60012 silicon diode and Gafchromics EBT2. Total scatter factors for a CyberKnife system were measured in circular fields with diameters from 5 to 60 mm. Dose profiles were measured for the 5- and 60-mm cones. The measurements were performed in a water tank at a 1.5-cm depth and an 80-cm source-axis distance.

RESULTS

The total scatter factors measured using all the detectors agreed within 1% with the Monte Carlo values for cones of 20 mm or greater in diameter. For cones of 10-20 mm in diameter, the PTW 60008 silicon diode was the only dosimeter whose measurements did not agree within 1% with the Monte Carlo values. For smaller fields (<10 mm), each dosimeter type showed different behaviors. The silicon diodes over-responded because of their water nonequivalence; the microLion and 1.0-mm PSD under-responded because of a volume-averaging effect; and the 0.5-mm PSD was the only detector within the uncertainties of the Monte Carlo simulations for all the cones. The PSDs, the PTW 60012 silicon diode, and the Gafchromics EBT2 agreed within 2% and 0.2 mm (gamma evaluation) for the measured dose profiles except in the tail of the 60-mm cone.

CONCLUSIONS

Silicon diodes can be used to accurately measure small-field dose profiles but not to measure total scatter factors, whereas PSDs can be used to accurately measure both. The authors' measurements show that the use of a 1.0-mm PSD resulted in a negligible volume-averaging effect (under-response of ≈1%) down to a field size of 5 mm. Therefore, PSDs are strong candidates to become reference radiosurgery detectors for beam characterization and quality assurance measurements.

摘要

目的

小射野剂量学颇具挑战性,大多数剂量仪的主要局限性是空间分辨率不足、水等效性差和能量依赖性。本研究的目的是通过在 CyberKnife 系统上测量总散射因子和剂量分布,将塑料闪烁体探测器(PSD)与几种商业立体定向剂量仪进行比较。

方法

研制了两个敏感体积分别为 0.196 和 0.785mm³的 PSD,并与其他探测器进行了比较。应用光谱甄别方法从信号中减去契伦科夫光。通过测量总散射因子,将两个 PSD 与四个商业立体定向剂量仪进行了比较,即 IBA 剂量学立体定向场二极管(SFD)、PTW 60008 硅二极管、PTW 60012 硅二极管和 microLion。进一步将测量的总散射因子与两项独立的蒙特卡罗研究进行比较。对于剂量分布,使用两个商业探测器进行比较,即 PTW 60012 硅二极管和 Gafchromics EBT2。在直径为 5 至 60mm 的圆形射野中测量 CyberKnife 系统的总散射因子。测量 5 和 60mm 圆锥的剂量分布。在水深 1.5cm 和源轴距 80cm 的水箱中进行测量。

结果

所有探测器测量的总散射因子与蒙特卡罗模拟值在直径为 20mm 或更大的圆锥体中相差在 1%以内。对于直径为 10-20mm 的圆锥体,只有 PTW 60008 硅二极管的测量值与蒙特卡罗模拟值相差在 1%以内。对于较小的射野(<10mm),每种剂量仪类型都表现出不同的行为。由于水等效性差,硅二极管会过度响应;由于体积平均效应,microLion 和 1.0mm PSD 会欠响应;而 0.5mm PSD 是所有圆锥体在蒙特卡罗模拟不确定性范围内唯一与测量值相符的探测器。PSD、PTW 60012 硅二极管和 Gafchromics EBT2 在测量的剂量分布方面的差异在 2%以内和 0.2mm(伽马评估)以内,除了 60mm 圆锥体的尾部。

结论

硅二极管可用于准确测量小射野剂量分布,但不能测量总散射因子,而 PSD 可用于准确测量这两者。作者的测量结果表明,使用 1.0mm PSD 可将体积平均效应(欠响应约 1%)降低至 5mm 的射野尺寸。因此,PSD 是成为用于束特性和质量保证测量的立体定向放射外科参考探测器的有力候选者。

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