Department of Orthopedic Surgery, Dongtai People's Hospital, No. 2 Kangfu West Road, Dongtai 224200, Jiangsu, China.
J Mater Sci Mater Med. 2013 Sep;24(9):2247-54. doi: 10.1007/s10856-013-4964-8. Epub 2013 Jul 6.
To improve the safety of dura repair in neurological surgeries, a new poly (glycolide-co-lactide)/type I collagen/chitosan artificial composite dura mater was evaluated in a rabbit model with dura mater injury. Eighteen rabbits were randomized to 3 groups: rabbits with unclosed dura mater; rabbits with dura mater repaired by fascia and rabbits with dura mater repaired by the composite membrane. Modified combine behavior score were given at a series of time points and several cytokines were also determined to reflect the inflammatory conditions. Rabbits whose dura mater was repaired by composite membrane showed a similar recovery rate of neurological function and inflammatory condition compared with the rabbits whose dura mater was repaired by fascia. In addition, the rabbits with closed dura mater were better than ones with unclosed dura mater in the restore rate of neurological function as well as inflammatory reactions according to the statistical analysis. The new artificial membrane appears to be safe and efficient in the treatment of dura mater defect.
为提高神经外科硬脑膜修复的安全性，本研究采用兔颅骨损伤模型评价了一种新型聚（乙交酯-丙交酯）/I 型胶原/壳聚糖人工复合硬脑膜。18 只兔子随机分为 3 组：硬脑膜未缝合组、筋膜修补硬脑膜组和复合膜修补硬脑膜组。在一系列时间点进行改良联合行为评分，并测定几种细胞因子以反映炎症情况。与筋膜修补硬脑膜的兔子相比，复合膜修补硬脑膜的兔子的神经功能和炎症情况恢复相似。此外，根据统计分析，硬脑膜缝合的兔子在神经功能恢复和炎症反应方面均优于硬脑膜未缝合的兔子。新型人工膜在硬脑膜缺损治疗中安全有效。
