铑催化的 1,2-氮杂硼杂环的硼芳基化反应。
Rhodium-catalyzed boron arylation of 1,2-azaborines.
机构信息
Department of Chemistry and Biochemistry, University of Oregon, Eugene, OR 97403-1253, USA.
出版信息
Angew Chem Int Ed Engl. 2013 Aug 26;52(35):9316-9. doi: 10.1002/anie.201304443. Epub 2013 Jul 5.
Abstract
UNLABELLED
A SN-PHONY IN B!: BN isosteres of biphenyl compounds are prepared through Rh-catalyzed cross-coupling between 2-chloro-1,2-azaborines and arylstannanes (see scheme). The synthetic method should enable investigations of structure–activity relationships (SARs) by expanding the chemical space of the pharmaceutically relevant biphenyl structure through BN/CC isosterism.
摘要
未标记
B 中的 SN-杂种!: 通过 Rh 催化的 2-氯-1,2-氮杂硼烷和芳基锡烷之间的交叉偶联反应制备双苯化合物的 BN 等排体（见方案）。该合成方法通过 BN/CC 等排体扩展了具有药用相关性的联苯结构的化学空间，从而可以通过扩展化学空间来进行结构-活性关系（SARs）的研究。
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