Rathi Badal, Bodhankar Subhash, Mohan V, Thakurdesai Prasad
Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune- 411 038, India.
Sci Pharm. 2013 Apr-Jun;81(2):567-89. doi: 10.3797/scipharm.1301-16. Epub 2013 Feb 25.
Cinnamon bark (Cinnamomum zeylanicum Syn C. verum, family: Lauraceae) is one of the oldest traditional medicines for inflammatory- and pain-related disorders. The objective of the present study was to evaluate the efficacy of the polyphenol fraction from Cinnamomum zeylanicum bark (CPP) in animal models of inflammation and rheumatoid arthritis. Dose-response studies of CPP (50, 100, and 200 mg/kg) used in a separate set of in vivo experiments were conducted in acute (carrageenan-induced rat paw edema), subacute (cotton pellet-induced granuloma), and sub-chronic (AIA, adjuvant-induced established polyarthrtis) models of inflammation in rats and the acetic acid-induced writhing model of pain in mice. Effects of CPP on cytokine (IL-2, IL-4, and IFNγ) release from Concanavalin (ConA)-stimulated lymphocytes were also evaluated in vitro. CPP showed a strong and dose-dependent reduction in paw volume, weight loss reversal effects against carrageenan-induced paw edema, and cotton pellet-induced granuloma models in rats. CPP (200 mg/kg p.o. for 10 days) showed a significant reduction in elevated serum TNF-α concentration without causing gastric ulcerogenicity in the AIA model in rats. CPP also demonstrated mild analgesic effects during acute treatment as evidenced by the reduction in the writhing and paw withdrawal threshold of the inflamed rat paw during the acetic acid-induced writhing model and Randall-Selitto test. CPP was found to inhibit cytokine (IL-2, IL-4, and IFNγ) release from ConA-stimulated lymphocytes in vitro. In conclusion, CPP demonstrated prominent action in animal models of inflammation and arthritis and therefore can be considered as a potential anti-rheumatic agent with disease-modifying action.
肉桂皮（锡兰肉桂，樟科）是治疗炎症和疼痛相关疾病最古老的传统药物之一。本研究的目的是评估锡兰肉桂皮多酚组分（CPP）在炎症和类风湿性关节炎动物模型中的疗效。在大鼠急性（角叉菜胶诱导的大鼠足爪水肿）、亚急性（棉球诱导的肉芽肿）和亚慢性（佐剂诱导的慢性关节炎，AIA）炎症模型以及小鼠醋酸诱导的扭体疼痛模型中，对单独一组体内实验中使用的CPP（50、100和200mg/kg）进行了剂量反应研究。还在体外评估了CPP对伴刀豆球蛋白（ConA）刺激的淋巴细胞释放细胞因子（IL-2、IL-4和IFNγ）的影响。CPP在大鼠足爪体积、角叉菜胶诱导的足爪水肿和棉球诱导的肉芽肿模型中显示出强烈且剂量依赖性的减轻作用。在大鼠AIA模型中，CPP（200mg/kg口服，持续10天）可显著降低升高的血清TNF-α浓度，且不会引起胃溃疡。在醋酸诱导的扭体模型和Randall-Selitto试验中，CPP在急性治疗期间也表现出轻度镇痛作用，表现为炎症大鼠足爪的扭体次数减少和足爪撤离阈值降低。体外研究发现，CPP可抑制ConA刺激的淋巴细胞释放细胞因子（IL-2、IL-4和IFNγ）。总之，CPP在炎症和关节炎动物模型中显示出显著作用，因此可被视为一种具有疾病改善作用的潜在抗风湿药物。
