Department of Bioinformatics, School of Computer and Information Sciences, Galgotias University, Greater Noida, India.
Curr Drug Targets. 2013 Sep;14(10):1110-7. doi: 10.2174/13894501113149990182.
The predominance of insulin resistance, T2D linked pancreatic cancer has increased throughout the world. The insulin/IGF signaling pathway related to insulin resistance, T2D and pancreatic cancer has been described. In this context, we have demonstrated the role of miRNAs in cancer progression and control of miRNAs in insulin/IGF signaling pathway, and pancreatic cancer. In this paper, an overview was depicted about the role of following miRNAs in pancreatic development and insulin secretion (miR-375, miR-7, miR-124a2, miR-195, miR-126, miR-9, miR-96, miR-34a); insulingrowth factor-1 receptor expression (miR-7, miR-139, miR-145, miR-1); the diabetes-associated pancreatic cancer pathway genes such as IRS, PI3K, AKT/PKB (miR-128a, miR-19a, miR-21, miR-29 a/b/c); mTOR protein regulation (miR- 99, miR-21, miR-126, and miR-146a) etc. At last, we have also explained the role of miRNAs in diagnostic marker (miR- 200, miR-21, miR-103, miR-107, and miR-155) and as a therapeutic modulator (miR-34, miR-21, miR-221, and miR-101) in pancreatic cancer.
胰岛素抵抗的优势，与 2 型糖尿病相关的胰腺癌在全球范围内有所增加。已经描述了与胰岛素抵抗、2 型糖尿病和胰腺癌相关的胰岛素/IGF 信号通路。在这方面，我们已经证明了 miRNAs 在癌症进展中的作用以及对胰岛素/IGF 信号通路和胰腺癌中 miRNAs 的控制作用。在本文中，概述了以下 miRNAs 在胰腺发育和胰岛素分泌中的作用（miR-375、miR-7、miR-124a2、miR-195、miR-126、miR-9、miR-96、miR-34a）；胰岛素生长因子-1 受体表达（miR-7、miR-139、miR-145、miR-1）；糖尿病相关的胰腺癌途径基因，如 IRS、PI3K、AKT/PKB（miR-128a、miR-19a、miR-21、miR-29a/b/c）；mTOR 蛋白调节（miR-99、miR-21、miR-126 和 miR-146a）等。最后，我们还解释了 miRNAs 在诊断标志物（miR-200、miR-21、miR-103、miR-107 和 miR-155）和作为治疗调节剂（miR-34、miR-21、miR-221 和 miR-101）在胰腺癌中的作用。
