School of Chemistry & Environment, South China Normal University, Guangdong Technology Research Center for Ecological Management and Remediation of Urban Water System, Higher Education Mega Center, Guangzhou 510006, People's Republic of China; Croucher Institute for Environmental Sciences and Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
Chemosphere. 2013 Oct;93(6):924-30. doi: 10.1016/j.chemosphere.2013.05.057. Epub 2013 Jul 6.
Human exposure to bioaccessible PCBs via indoor dust is limited around the world. In the present study, the workplace dust sample from commercial office, hospital, secondary school, shopping mall, electronic factory and manufacturing plant were collected from Hong Kong for PCBs analyses. Total PCBs concentrations ranged from 46.8 to 249 ng g(-1), with a median of 107 ng g(-1). Manufacturing plant showed the highest concentration among all of sampling sites. PCB 77 was found as the dominant congeners. The bioaccessibility of PCBs in small intestinal juice ranging from 8.3% to 26.0% was significantly higher than that in gastric condition, ranging from 4.8% to 12.4%. In addition, significant negative correlations (p<0.05) were observed between KOW and bioaccessibility for all workplace dust samples. Risk assessment indicated that the averaged daily dose of dioxin-like PCBs via non-dietary intake of workplace dust, considering the bioaccessibility of PCBs, were much lower than the TDI of dioxins (2.3 pg WHO-TEQ kgbw(-1)d(-1)) established by Joint FAO/WHO Expert Committee on Food Additives.
全世界人类通过室内灰尘接触到的生物可利用多氯联苯是有限的。在本研究中，从香港的商业写字楼、医院、中学、购物中心、电子工厂和制造厂采集了工作场所灰尘样本，用于多氯联苯分析。多氯联苯总浓度范围为 46.8 至 249 ng/g，中位数为 107 ng/g。所有采样点中，制造厂的浓度最高。研究发现 PCB77 是主要的同系物。在小肠液中的生物可利用度范围为 8.3%至 26.0%，明显高于在胃中的生物可利用度范围 4.8%至 12.4%。此外，所有工作场所灰尘样本中，KOW 与生物可利用度之间呈显著负相关（p<0.05）。风险评估表明，考虑到多氯联苯的生物可利用度，通过非饮食途径摄入工作场所灰尘中的二恶英类多氯联苯的平均日剂量远低于粮农组织/世界卫生组织食品添加剂联合专家委员会制定的二恶英（2.3 pg WHO-TEQ/kgbw/d）的 TDI。
