State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P R China.
Chem Biodivers. 2013 Jul;10(7):1317-21. doi: 10.1002/cbdv.201200395.
One new carbazole alkaloid, excavatine A (1), and two additional new alkaloids, excavatine B (2) and excavatine C (3), were isolated from the stems and leaves of Clausena excavata Burm.f. (Rutaceae). Their structures were determined on the basis of detailed spectroscopic analyses, especially 2D-NMR and HR-EI-MS data. Compounds 1-3 were tested for their cytotoxic activities against A549, HeLa, and BGC-823 cancer cell lines, and for their antimicrobial activities against Candida albicans and Staphylococcus aureus. Only 1 exhibited cytotoxicity against A549 and HeLa cell lines with the IC50 values of 5.25 and 1.91 μg/ml, respectively.
从吴茱萸科（ Rutaceae ）植物石虎（ Clausena excavata Burm.f. ）的茎和叶中分离得到了 1 个新的咔唑生物碱（ 1 ）和另外 2 个新生物碱（ 2 和 3 ）。基于详细的光谱分析，特别是二维 NMR 和高分辨 EI-MS 数据，确定了它们的结构。测试了化合物 1-3 对 A549 、 HeLa 和 BGC-823 癌细胞系的细胞毒性活性，以及对白色念珠菌和金黄色葡萄球菌的抗菌活性。只有化合物 1 对 A549 和 HeLa 细胞系表现出细胞毒性，IC50 值分别为 5.25 和 1.91μg/ml。
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